Recombinant Drosophila melanogaster WW domain-containing oxidoreductase(Wwox)

Code CSB-YP893301DLU
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Source Yeast
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Code CSB-EP893301DLU
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Source E.coli
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Code CSB-EP893301DLU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP893301DLU
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Source Baculovirus
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Code CSB-MP893301DLU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Wwox
Uniprot No. Q9VLU5
Alternative Names Wwox; CG7221; WW domain-containing oxidoreductase; EC 1.1.1.-
Species Drosophila melanogaster (Fruit fly)
Expression Region 1-409
Target Protein Sequence MIALPDTDSE DELPPGWEER ATDDGTVCYV NQQGKTSQWT HPRTGRSKRI TGELPLGWEK YYDEQGKRFM FLNKETQQRT NVDPRLAFAV EEPTQNVAQV RQRFDSCSTA LQVLHGKDLH GRTALITGAN CGIGYETARS LAHHGCEIIF ACRNRSSAEA AIERIAQERP AARSRCRFAA LDLSSLRSVQ RFVEEIKQSV SHIDYLILNA GVFALPYTRT VDGLETTFQV SHLSHFYLTL QLETLFDYKT RIIVLSSESH RFANLPVENL AVHHLSPPPE KYWSMMAYNN AKLCNVLFAQ ELAQRWKQRG ISVFSLHPGN MVSSDLSRNY WFYRLLFAIV RPFTKSLQQA AATSIYCATA NELTGLSGLY FNNCFFCEPS KLSKSAALQQ QLWKLSENLI AELVEQEQH
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Putative oxidoreductase. May control genotoxic stress-induced cell death. May play a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. May play a role in Wnt signaling.
Gene References into Functions
  1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity. PMID: 26390919
  2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity. PMID: 26302329
  3. Aberrant WWOX expression contributes to the altered metabolism in cancer. PMID: 25595186
  4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX PMID: 21075834
  5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX PMID: 16007179

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Subcellular Location Cytoplasm.
Protein Families Short-chain dehydrogenases/reductases (SDR) family
Database Links

KEGG: dme:Dmel_CG7221

STRING: 7227.FBpp0079172

UniGene: Dm.19795

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