Ybx1 Antibody

1. The study establishes YBX1 as a posttranscriptional effector required for maintenance of epidermal homeostasis. PMID: 29712925
2. his is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury. PMID: 29353823
3. YB-1 orchestrates onset and resolution of renal inflammation via IL-10 gene regulation. PMID: 28664613
4. Monocytic YB-1 has prominent and distinct roles for cellular feed-forward crosstalk and resolution of inflammatory processes by its ability to regulate cell differentiation and cytokine/chemokine synthesis. PMID: 28610763
5. this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2 PMID: 27694635
6. In conclusion, TGF-beta signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis. PMID: 28153731
7. Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs, suggesting their roles in further regulation of the pluripotent state of ESCs. PMID: 26289635
8. YB-1 is a novel intracellular target of activated protein C in renal ischemia-reperfusion injury PMID: 26015455
9. miR-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein. PMID: 25292190
10. YB-1 was revealed in a population of Cajal bodies in 2-cell mouse embryos but not in other cells studied. PMID: 25175035
11. The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis. PMID: 24349210
12. The formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-1, which promotes MMTV virus assembly. PMID: 24501406
13. our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses. PMID: 23872051
14. The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines. PMID: 23285076
15. Results indicate that both CD4(+) and CD8(+) T cells were involved in the anti-neuroblastoma responses induced by YB-1 immunization combined with Treg depletion. PMID: 23169344
16. findings show heterotopic cardiac transplant resulted in accumulation of 50-kDa YB-1 polypeptide within the polyribosome-enriched cytosol proximal to cardiac intercalated discs; YB-1 may govern cell response in the transplanted heart through its ability to bind and protect injury-activated mRNA transcripts that are prioritized for translation to assure graft adaptation PMID: 22619371
17. Extracellular inhibitory targeting of YB-1 potently induces glomerular Notch-3 receptor expression. PMID: 21372592
18. These results suggest that in skeletal muscle cells, neural activity reduces the molar ratio of YB-1 relative to its binding AChR alpha mRNA, leading to an increase of ribosome binding to the mRNA, and thus activating translation. PMID: 21964286
19. YBX1 is highly expressed in erythroid myeloid lymphoid-clone 1 (EML), a hematopoietic precursor cell line, but is down-regulated in myeloid progenitors and GM-CSF-treated EML cells during the course of myeloid differentiation. PMID: 21369783
20. A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice. PMID: 21115500
21. These results suggest that in the brain of growing mice, YB-1 binds to GluR2 and CaM1 mRNAs and regulates their translation in an activity-dependent manner. PMID: 20614234
22. YB-1 functions under the regulation of GATA factors in erythroid differentiation and aberrant expression of YB-1 gene may result in dyserythropoiesis PMID: 12646178
23. we biochemically identified a Sox21-associating protein, Y-box binding protein 1 which not only binds to Sox21 but also partially restores NGF-induced neurite outgrowth of PC12 cells inhibited by Sox21. PMID: 15039105
24. YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance. PMID: 15072594
25. YB-1 normally represses the transcription of CDK inhibitors, making it an important component of the cellular stress response signaling pathway. PMID: 15899865
26. Association of YB-1 with the capped 5' terminus of the mRNA is regulated via phosphorylation by the serine/threonine protein kinase Akt. PMID: 16354698
27. the functional importance of the NSEP1 gene in murine early embryonic development PMID: 16598782
28. FBX33 as a component of an SCF E3-ubiquitin ligase that targets the multifunctional regulator Y-box binding protein 1 (YB-1)/dbpB/p50 for polyubiquitination and destruction by the proteasome. PMID: 16797541
29. The expression and polysome association of YB-1 in various tissues at different stages in the lifespan of mice PMID: 17045744
30. YB-1 is involved in early mouse development, including neural tube closure and cell proliferation. PMID: 17082189
31. conclude that HER-2 overexpressing as well as triple-negative breast cancer cells are YB-1 dependent, suggesting it may be a good therapeutic target for these exceptionally aggressive tumors PMID: 18974106
32. YB-1 transcription in the postnatal brain is regulated by a bHLH transcription factor Math2 through an E-box sequence in the 5'-UTR of the gene PMID: 19225866
33. Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice. PMID: 19272383
34. Data demonstrate that extracellular YB-1 associates with outer cell membrane components and interacts with extracellular Notch-3 receptor domains. PMID: 19640841

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KEGG: mmu:22608

STRING: 10090.ENSMUSP00000078589

UniGene: Mm.258204