Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YME1 Polyclonal antibody

Uniprot No.

P32795

Target Names

YME1

Alternative Names

YME1 antibody; OSD1 antibody; YTA11 antibody; YPR024W antibody; YP9367.04 antibody; Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 antibody; EC 3.4.24.- antibody; Protein OSD1 antibody; Tat-binding homolog 11 antibody; Yeast mitochondrial escape protein 1 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YME1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Catalytic subunit of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. The protease is probably ATP-dependent. Important to maintain the integrity of the mitochondrial compartment. Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain. Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary.

Gene References into Functions

this study presents an atomic model of a substrate-bound inner mitochondrial membrane AAA+ quality control protease in yeast, YME1. PMID: 29097521
Yme1 role in Tim10 degradation PMID: 26182355
identify an important role for the mitochondrial protease Yme1 in the ability of cells that lack tafazzin function to maintain mitochondrial structural integrity and mitochondrial quality control and to undergo mitophagy PMID: 25688091
No individual cysteine residue is required for the function of Tim9 or Tim10 in yeast and defective assembly of the small TIMs induces their proteolytic clearance from mitochondria via the mitochondrial ATP-dependent protease, Yme1. PMID: 23036860
Inactivation of either Yme1 or Yta10/12, allows fermentative growth of hsc82 or hsp82 strains at 37 degrees C. PMID: 21439406
Yme1 has a new function in protein translocation, indicating that the intermembrane space harbors diverse pathways for protein translocation. PMID: 16966379
There are two distinct substrate binding sites in the i-AAA protease subunit Yme1. PMID: 17261594
The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components OXA1 and YME1. PMID: 17976194

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Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Although this protein does not have any predicted transmembrane helices it behaves like an integral membrane protein.

Protein Families

AAA ATPase family; Peptidase M41 family

Database Links

KEGG: sce:YPR024W

STRING: 4932.YPR024W

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YME1 Antibody

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