YOR1 Antibody

Code CSB-PA345644XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YOR1 Polyclonal antibody
Uniprot No.
Target Names
YOR1
Alternative Names
YOR1 antibody; YGR281W antibody; Oligomycin resistance ATP-dependent permease YOR1 antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) YOR1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups. Required for tolerance to reveromycin A, tautomycin and leptomycin B. Required for oligomycin resistance. Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B. Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex. Confers resistance to rhodamine 6G and to doxorubicin.
Gene References into Functions
  1. Data reveal that it is possible to modulate activity of ABC transporters Yor1p by physically replacing dysfunctional domains. PMID: 20843810
  2. Strains expressing Yor1p display an energy-dependent efflux of cadmium estimated for the yeasts overexpressing Yor1p to be about 0.02 nmol 109Cd/mg protein/min. PMID: 16814918
  3. Endoplasmic reticulum quality control checkpoint engages misfolded Yor1p even after it has been stabilized by inhibition of the degradative pathway. PMID: 17615300
  4. Yor1p also confers resistance to rhodamine 6G and to doxorubicin. PMID: 17950691
  5. Mapping of interdomain interfaces required for the functional architecture of Yor1p, a eukaryotic ATP-binding cassette (ABC) transporter PMID: 18644782

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Database Links

KEGG: sce:YGR281W

STRING: 4932.YGR281W

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