YRA1 Antibody

1. Yra1 binds RNA-DNA hybrids in vitro and, when artificially overexpressed, can be recruited to chromatin in an RNA-DNA hybrid-dependent manner, stabilizing R loops and converting them into replication obstacles in vivo PMID: 29954833
2. YRA1 overexpression causes a cell senescence-like phenotype and telomere shortening PMID: 27035147
3. These data show that Yra1 inhibits unwinding in a concentration-dependent manner by preventing the association of Dbp2 with single-stranded RNA. PMID: 26876600
4. the phospho-CTD is likely involved directly in the cotranscriptional recruitment of Yra1. PMID: 21856751
5. Data indicate that Edc3p-mediated YRA1 pre-mRNA decay occurs independently of translation and also requires Mex67p. PMID: 20463951
6. We propose that appropriate levels of Yra1p are maintained by inefficient cotranscriptional splicing. PMID: 16618971
7. YRA1p can bind to nascent mRNAs, heat shock RNA was exported efficiently in temperature-sensitive YRA1 mutant strains PMID: 17259545
8. YRA1 exon 1 sequences in cis and Yra1p in trans inhibit YRA1 pre-mRNA splicing and commit the pre-mRNA to nuclear export. PMID: 17317628
9. Dia2 binding to replication origins is significantly reduced when association with Yra1 is compromised PMID: 17452447
10. Nap1 interacts directly with Yra1. The recruitment of Nap1 to the coding region of actively transcribed genes is Yra1 dependent. PMID: 18227150
11. Yra1 binds directly to the Zn finger/Clp1 region of Pcf11, the pol II CTD-binding subunit of CF1A. PMID: 19110458

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KEGG: sce:YDR381W

STRING: 4932.YDR381W