dps Antibody

Code CSB-PA337381ZA01HUV
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Product Details

Full Product Name
Rabbit anti-Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) dps Polyclonal antibody
Uniprot No.
Target Names
dps
Alternative Names
dps antibody; napA antibody; HP_0243DNA protection during starvation protein antibody; EC 1.16.-.- antibody; Bacterioferritin antibody; HP-NAP antibody; Neutrophil-activating protein A antibody; NAP A antibody
Raised in
Rabbit
Species Reactivity
Helicobacter pylori
Immunogen
Recombinant Helicobacter pylori dps protein
Immunogen Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases.
Gene References into Functions
  1. H. pylori NapA has unique and separate roles in gastric pathogenesis. PMID: 17030577
Subcellular Location
Cytoplasm.
Protein Families
Dps family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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