gB Antibody

Datasheet

Code	CSB-PA355975ZA01EFA
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: gB antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 43.3 kDa Observed band size: 46 kDa
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Target Background

Product Details

Uniprot No.

P03188

Target Names

Alternative Names

Envelope glycoprotein B (gB), gB

Species Reactivity

Epstein-Barr virus

Immunogen

Recombinant Epstein-Barr virus gB protein (23-260aa)

Immunogen Species

Epstein-Barr virus

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The generation of the gB polyclonal antibody involves a systematic approach. It starts with multiple immunization rounds of a rabbit using recombinant Epstein-Barr virus gB protein (23-260aa) until an adequate antibody titer is reached. Following this, the rabbit's blood is collected, and the antibodies are isolated from the serum employing protein G. The functionality of the resulting gB antibody is extensively tested in both ELISA and WB applications, confirming its precise reactivity with the Epstein-Barr virus gB protein.

Epstein-Barr virus (EBV) glycoprotein B (gB) is a class III viral fusogen and serves a pivotal function in mediating the fusion of the viral envelope with the host cell membrane. When activated, gB is believed to insert fusion loops into the target cell membranes and undergo refolding from a prefusion to a postfusion conformation, enabling the fusion of these membranes. Beyond its fusogenic role, gB is indispensable for viral replication, and the absence of the gB gene results in the inability to generate EBV.

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Target Background

Function

Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.

Gene References into Functions

These studies indicate that the cytoplasmic tail domain is important in the cellular localization, expression, and fusion function of Epstein-Barr virus gB. PMID: 23341550
These data demonstrate that the bulky and hydrophobic EBV loop residues, which differ from the more hydrophilic HSV-1 residues and appear more compatible with membrane insertion, are essential for EBV gB-dependent fusion. PMID: 17553877
Fusion activity was abolished in all but three variants containing mutations in the N-terminal region (gB30), within the ectodomain (gB421), and in the intracellular C-terminal domain (gB832) of the protein. PMID: 18987135

Subcellular Location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.

Protein Families

Herpesviridae glycoprotein B family

Database Links

KEGG: vg:3783680

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gB Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background