gL Antibody

Datasheet

Code	CSB-PA355982ZA01EFA
Size	US$299
Image	Western Blot Positive WB detected in: recombinant protein All lanes: gL Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 43 kDa Observed band size: 43 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) gL Polyclonal antibody

Uniprot No.

P03212

Target Names

Alternative Names

Envelope glycoprotein L (gL), gL

Raised in

Rabbit

Species Reactivity

Epstein-Barr virus

Immunogen

Recombinant Epstein-Barr virus gL protein (23-137aa)

Immunogen Species

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.

Gene References into Functions

Here, the authors demonstrate that the BKRF2 gene behaves as a true-late lytic gene, whereas the BKRF3 and BKRF4 genes belong to the early lytic gene family. The results further reveal that both BKRF3 and BKRF4 promoters are new synergistic targets of Zta and Rta, two Epstein-Barr virus latent-to-lytic switch transactivators. PMID: 30096410
The critical regulator of EBV tropism is the gp42 N-terminal domain, which tethers the HLA-binding domain to gHgL by wrapping around the exterior of three gH domains. PMID: 27929061
Findings suggest that EBV gH/gL detection complements viral capsid antigen (VCA) detection in the diagnosis of nasopharyngeal carcinoma (NPC) and aids in the identification of patients with VCA-negative NPC. PMID: 27093005
The KGD motif of Epstein-Barr virus gH/gL directs EBV fusion of B cells and epithelial cells. PMID: 22215569
Data show that the gL subunit and N-terminal residues of gH form a globular domain at one end of the structure. PMID: 21149717

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Subcellular Location

Virion membrane; Peripheral membrane protein; Extracellular side. Host cell membrane; Peripheral membrane protein; Extracellular side. Host Golgi apparatus, host trans-Golgi network.

Protein Families

Herpesviridae glycoprotein L family

Database Links

KEGG: vg:3783710

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gL Antibody

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