Interleukin 6 (IL-6) is a multifunctional cytokine that plays essential roles in immune responses, inflammation, and hematopoiesis. This pleiotropic protein regulates acute-phase responses, promotes B-cell differentiation and antibody production, and influences T-cell activation. IL-6 also functions in metabolic processes and tissue repair mechanisms. Dysregulated IL-6 expression is associated with various pathological conditions. This makes it an important biomarker for inflammatory diseases, autoimmune disorders, and certain malignancies. Its diverse biological activities have made IL-6 a key research target for understanding immune system function and developing therapeutic interventions.
The Hamster Interleukin 6,IL-6 ELISA Kit (CSB-E14304Ha) is designed for quantitative measurement of IL-6 in Mesocricetus auratus samples. This sandwich ELISA works with serum, plasma, cell culture supernates, and tissue homogenates. Detection range spans 7.8 pg/mL to 500 pg/mL with sensitivity of 1.95 pg/mL. The assay requires 50-100 μL sample volume and can be completed within 1-5 hours. Detection occurs at 450 nm wavelength, providing researchers with a reliable tool for IL-6 quantification in golden hamster studies.
Application Examples
Note: The following application examples are drawn from a selection of publications citing this product. For additional applications, please refer to the full list of references in the "Citations" section.
This ELISA kit has been used in research investigating inflammatory responses and cytokine profiling in hamster models. Studies have applied the kit to measure interleukin-6 levels in various biological samples including serum and tissue homogenates. The applications span infectious disease research and immunological studies examining cytokine production patterns.
• Infectious disease research: Measurement of IL-6 levels in serum samples from hamsters infected with different viral strains to assess inflammatory responses compared to non-infected controls
• Respiratory immunology: Quantification of IL-6 concentrations in lung tissue homogenates as part of comprehensive cytokine profiling studies
• Cellular immunology: Analysis of IL-6 production in bone marrow-derived dendritic cell culture supernatants alongside other inflammatory mediators
• Comparative cytokine profiling: Integration with other cytokine measurements to evaluate comprehensive inflammatory response patterns in experimental models
