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Human Bone morphogenetic protein 8A(BMP8A) ELISA kit

Citations (2) Protocol MSDS
Code CSB-EL002745HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
bone morphogenetic protein 8a
Alternative Names
BMP-8A ELISA Kit; BMP8 ELISA Kit; Bmp8a ELISA Kit; BMP8A_HUMAN ELISA Kit; Bone morphogenetic protein 8A ELISA Kit; FLJ14351 ELISA Kit; FLJ45264 ELISA Kit; OP 2 ELISA Kit; Osteogenic protein 2 ELISA Kit
Abbreviation
BMP8A
Uniprot No.
Q7Z5Y6
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates, cell lysates
Detection Range
37.5 pg/mL-2400 pg/mL
Sensitivity
9.38 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Stem Cells
Assay Principle
quantitative
Measurement
Sandwich
ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human BMP8A ELISA Kit was designed for the quantitative measurement of Human BMP8A protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 37.5 pg/mL-2400 pg/mL and the sensitivity is 9.38 pg/mL.

Citations

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Target Background

Function
(From Uniprot)
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
Gene References into Functions
  1. Authors found that Bmp8a, but not Bmp8b, was expressed predominantly in the neonatal mouse spermatogonia. Although most BMPs induce activation of SMADs 1, 5, and 8 (SMAD1/5/8), but not SMADs 2 and 3 (SMAD2/3), they found that BMP8A induced signaling through both sets of transcription factors. PMID: 28465413
  2. Observational study of gene-disease association. (HuGE Navigator) PMID: 20424473
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20237496
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Database Links

HGNC: 21650

KEGG: hsa:353500

STRING: 9606.ENSP00000327440

UniGene: Hs.472497

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Related pathways
Hippo signaling pathway TGF-beta signaling pathway
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