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Human Chitinase-3-like protein 2(CHI3L2) ELISA kit

Citations (1) Protocol MSDS
Code CSB-EL005347HU
Size 96T,5×96T,10×96T
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Product Details

Alternative Names
CH3L2_HUMAN ELISA Kit; CHI3L2 ELISA Kit; Chitinase 3 like 2 ELISA Kit; Chitinase-3-like protein 2 ELISA Kit; Chondrocyte protein 39 ELISA Kit; OTTHUMP00000014028 ELISA Kit; YKL 39 ELISA Kit; YKL-39 ELISA Kit; YKL39 ELISA Kit
Abbreviation
CHI3L2
Uniprot No.
Q15782
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.78 ng/ml-50 ng/ml
Sensitivity
0.19 ng/ml
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Stem Cells
Assay Principle
quantitative
Measurement
Sandwich
Precision

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

Linearity

To assess the linearity of the assay, samples were spiked with high concentrations of human CHI3L2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

　

Sample

Serum(n=4)

1:1

Average %

87

Range %

81-91

1:2

Average %

101

Range %

95-105

1:4

Average %

102

Range %

98-109

1:8

Average %

96

Range %

91-98

Recovery

The recovery of human CHI3L2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type

Average % Recovery

Range

Serum (n=5)

94

89-96

EDTA plasma (n=4)

96

91-98

Typical Data

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml

OD1

OD2

Average

Corrected

50

2.701

2.688

2.695

2.582

25

2.344

2.192

2.268

2.155

12.5

1.704

1.729

1.717

1.604

6.25

1.151

1.137

1.144

1.031

3.125

0.678

0.699

0.689

0.576

1.56

0.388

0.366

0.377

0.264

0.78

0.238

0.241

0.240

0.127

0

0.115

0.111

0.113

　

ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Shelf Life
6 months
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.

Citations

Related Products

CHI3L2 Antibodies

CHI3L2 Proteins

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Target Background

Function
(From Uniprot)
Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
Gene References into Functions
  1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
  2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
  3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
  4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
  5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103

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Subcellular Location
Secreted.
Protein Families
Glycosyl hydrolase 18 family
Tissue Specificity
Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
Database Links

HGNC: 1933

OMIM: 601526

KEGG: hsa:1117

STRING: 9606.ENSP00000358763

UniGene: Hs.514840

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