CHI3L2 Antibody, Biotin conjugated

Code CSB-PA620893LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CHI3L2 Polyclonal antibody
Uniprot No.
Target Names
CHI3L2
Alternative Names
CH3L2_HUMAN antibody; CHI3L2 antibody; Chitinase 3 like 2 antibody; Chitinase-3-like protein 2 antibody; Chondrocyte protein 39 antibody; OTTHUMP00000014028 antibody; YKL 39 antibody; YKL-39 antibody; YKL39 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Chitinase-3-like protein 2 protein (27-390AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
Gene References into Functions
  1. This study shown that CHI3L2 is regulated differently in healthy and late onset Alzheimer"s disease brain depending on the sex. PMID: 27653898
  2. Structural analysis demonstrates that YKL-39 interacts with chitooligosaccharides through hydrogen bonds and hydrophobic interactions. Thermodynamic analysis indicates that binding of chitooligosaccharide to YKL-39 is mainly driven by enthalpy. PMID: 25477513
  3. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. PMID: 23291184
  4. YKL-39 possesses a chitinase-like fold, but lacks key active-site residues required for catalysis. PMID: 22742450
  5. ERK1/2 phosphorylation by CHI3L2 inhibits cell mitogenesis and proliferation. PMID: 22211103

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Subcellular Location
Secreted.
Protein Families
Glycosyl hydrolase 18 family
Tissue Specificity
Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
Database Links

HGNC: 1933

OMIM: 601526

KEGG: hsa:1117

STRING: 9606.ENSP00000358763

UniGene: Hs.514840

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