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| Code | CSB-EL009727HU |
| Size | 96T,5×96T,10×96T |
| Price | Request a Quote or Start an on-line Chat |
| Trial Size |
24T ELISA Kit Trial Size (Only USD$150/ kit) * The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now |
This human GPNMB ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human GPNMB in serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the GPNMB levels in the sample and is measured at 450 nm through a microplate reader.
GPNMB has different functions on distinct cell types. In bones, GPNMB promotes differentiation of osteoblasts and mineralization of bone matrix, fibroblast activation, and proliferation, maturation of hematopoietic and lymphoid cells, and also decreases the activation of lymphocytes T. Also, GPNMB expression is detected in multiple other tissues such as kidney and skeletal muscle where it participates in various processes like cell proliferation, tumor progression, and tissue regeneration. In humans, GPNMB serum levels are related and contribute to obesity and metabolic parameters such as hip circumference, body mass index, and insulin resistance. GPNMB also has a function as a negative regulator of inflammatory processes. It has been associated with various pathological conditions such as colitis, nonalcoholic steatohepatitis, amyotrophic lateral sclerosis, glaucoma, neuroinflammation, and cancer progression.
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