Human Troponin I, fast skeletal muscle(TNNI2) ELISA kit

Instructions
Code CSB-EL024012HU
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name troponin I type 2 (skeletal, fast)
Alternative Names AMCD 2B ELISA Kit; AMCD2B ELISA Kit; DA 2B ELISA Kit; DA2B ELISA Kit; fast skeletal muscle ELISA Kit; Fast twitch skeletal muscle troponin I ELISA Kit; fast-twitch isoform ELISA Kit; FSSV ELISA Kit; fsTnI ELISA Kit; TNNI 2 ELISA Kit; Tnni2 ELISA Kit; TNNI2_HUMAN ELISA Kit; tro ELISA Kit; Troponin I ELISA Kit; Troponin I fast skeletal muscle ELISA Kit; Troponin I fast twitch 2 ELISA Kit; Troponin I fast twitch isoform ELISA Kit; Troponin I fast twitch skeletal muscle isoform ELISA Kit; Troponin I skeletal fast ELISA Kit; Troponin I type 2 (skeletal fast) ELISA Kit; Troponin I type 2 ELISA Kit
Abbreviation TNNI2
Uniprot No. P48788
Species Homo sapiens (Human)
Sample Types serum, plasma,tissue homogenates
Detection Range 15.6 pg/mL-1000 pg/mL
Sensitivity 3.9 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Signal Transduction
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

Q&A and Customer Reviews

 Q&A
Q:

Per customer request, can you please provide the following information about this kit:
a. Capture antibody or capture antigen – immunogen type, sequence (including species source and accession no. if available), expression host, clonality and host species.
b. Detection antibody (if applicable) - immunogen type, sequence (including species source and accession no. if available), expression host, clonality and host species.
c. Standard – if recombinant protein please specify sequence (including species source and accession no. if available) and expression host.
d. The customer is asking about cross-reactivity with homologous proteins, espessialy with cTnI. Did you test it? Can you please provide such kind of information with data?

A:
Thanks for your inquiry!
CSB-EL024012hu
This kit is designed against full length protein.
Capture antibody is goat polyclonal antibody.
Detection antibody is goat polyclonal antibody.
Immunogen of capture antibody is 293 cell derived recombinant protein, full length.
Immunogen of detection antibody is 293 cell derived recombinant protein, partial.
Standard is 293 cell derived recombinant protein.There is no cross reactivity with cTnI.

Target Data

Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene References into Functions
  1. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. PMID: 28436080
  2. TNNI2 gene missense mutation is associated with distal arthrogryposis type 1. PMID: 26374086
  3. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism PMID: 23850728
  4. Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis. PMID: 22519952
  5. Atrial re-expression of ssTnI during paroxysmal atrial fibrillation in patients does not seem to be part of the process of AF-associated cardiomyocyte dedifferentiation but seems to result from transient cardiomyocyte stress at the onset of AF. PMID: 15289369
  6. study found a novel TNNI2 mutation in a Chinese family with distal arthrogryposis type 2B PMID: 16802141
  7. Implantation of stable human clone expressing fast-twitch skeletal muscle troponin I in female BALB/c nude mice inhibits primary tumor growth and suggests that grafts are self-inhibitory by halting angiogenesis. PMID: 17393089
  8. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha. PMID: 18331830
  9. Data found that fTnI normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnI transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes. PMID: 18548613
  10. Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. PMID: 18805052

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Involvement in disease Arthrogryposis, distal, 2B (DA2B)
Protein Families Troponin I family
Database Links

HGNC: 11946

OMIM: 191043

KEGG: hsa:7136

STRING: 9606.ENSP00000252898

UniGene: Hs.523403

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