Human adrenomedullin 2 (ADM2) ELISA kit

1. IMD may be an important self-protective factor in response to sepsis. PMID: 29980671
2. The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resistance to high-fat diet-induced obesity with increased energy expenditure. PMID: 27621315
3. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
4. ADM-2 is a stress-inducible gene controlled by ATF-4. PMID: 27328454
5. Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho via the calcitonin receptor/modifying protein complex and protein kinase A signaling. PMID: 26880455
6. Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury. PMID: 26743504
7. Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer. PMID: 26406405
8. ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 and decreasing MUC1 expression to facilitate trophoblast invasion. PMID: 26510869
9. Plasma intermedin and BNP levels were markedly higher in acute coronary syndrome patients than in healthy people. PMID: 23391507
10. High levels of ADM2 expression predict a poorer survival in patients with pancreatic adenocarcinoma. PMID: 25982376
11. TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries. PMID: 25102228
12. Intermedin affects the endothelial cell junction and blood vessel sprouting in a VE-cadherin dependent way. PMID: 25637664
13. results suggest that high plasma intermedin level is associated with poor outcomes of patients and may be a useful prognostic biomarker in ST-segment elevation acute myocardial infarction. PMID: 24969626
14. ADM and IMD mRNA expression are elevated in chronic heart failure at different stages of the disease. PMID: 24531032
15. a significant increase in plasma intermedin following acute myocardial infarction may be associated with oxidative stress, and could be used as a marker to reflect the severity of the coronary stenosis PMID: 23499766
16. this study is the first to demonstrate a potential involvement of IMD in human embryo implantation and placental development via regulation of trophoblast invasion at the maternal-fetal interface PMID: 23337723
17. Intermedin plays a critical role in the vascular remodeling process and tumor angiogenesis by regulating vascular endothelial-cadherin and extracellular signal-regulated kinase. PMID: 22922959
18. adm2 polymorphism is associated with renal dysfunction, blood pressure regulation and asymptomatic cerebrovascular diseases in the Japanese general population PMID: 21832999
19. potentially involved in regulating HLA-G antigen at the maternal-fetal interface and facilitating trophoblast invasion and migration via MAPK3/1 phosphorylation PMID: 21816853
20. Data showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. PMID: 22009752
21. Intermedin reduces HUVEC permeability via Rac1-mediated actin cytoskeleton rearrangement. PMID: 21816966
22. Adrenomedullin-related peptide, AM2 was highly expressed in colorectal cancer tissue. The percent increase of AM2 synthesis in cancer tissues to the surrounding normal tissues was greater than adrenomedullin. PMID: 21839130
23. IMD may be an endogenous vasoprotective factor for vascular calcification PMID: 19910445
24. may have a role in the physiology of human pregnancy via regulation of trophoblast invasion and migration PMID: 19535789
25. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes PMID: 14615490
26. ADM2 may be related to the central and peripheral regulation of the circulation and water-electrolyte metabolism PMID: 16359754
27. IMD expressed by pericytes in has a role in susceptibility of the skin of atopic dermatitis patients to inflammatory stimuli PMID: 17008878
28. Study has shown expression of AM2/IMD in various types of cells in the central nervous system and the cardiovascular system, and suggested possible (patho)physiological roles of AM2/IMD in these systems. PMID: 17346853
29. robust increase in expression of the peptide in hypertrophied and ischaemic myocardium indicates an important protective role for adrenomedullin 2 as an endogenous counter-regulatory peptide in the heart--REVIEW PMID: 17965749
30. adrenomedullin 2/intermedin may have autocrine/paracrine regulatory roles in adrenal tumors and attached non-neoplastic adrenal tissues, such as tumor growth. PMID: 18460550
31. Vascular injury in rat kidney is reduced by IMD gene delivery and it prevents glomerular and peritubular capillary loss. PMID: 18829738
32. Data show that adrenomedullin-2 was shown to be secreted by HAEC and may play a potential protective role in human aortic endothelial cells. PMID: 19255504
33. IMD enhances angiogenesis through ERK, Akt/NOS/NO, and VEGF/VEGFR-2 signaling pathways PMID: 19592612
34. IMD is a novel hypoxia-induced gene and a potential interventional agent for the improvement of endothelial barrier function in systemic inflammatory responses and hypoxia-induced vascular leakage. PMID: 19684198

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HGNC: 28898

OMIM: 608682

KEGG: hsa:79924

STRING: 9606.ENSP00000379086

UniGene: Hs.449099