Human neuregulin-4 (NRG4) ELISA kit

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Human neuregulin-4 (NRG4) ELISA kit

Name: Human neuregulin-4 (NRG4) ELISA kit
Brand: CUSABIO
SKU: CSB-EL016080HU

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Code	CSB-EL016080HU
Size	96T,5×96T,10×96T
Trial Size
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Target Background

Target Name

neuregulin-4 (NRG4)

Alternative Names

DKFZp779N0541 ELISA Kit; DKFZp779N1944 ELISA Kit; Heregulin 4 ELISA Kit; HRG4 ELISA Kit; Neuregulin 4 ELISA Kit; Neuregulin-4 ELISA Kit; NRG-4 ELISA Kit; NRG4 ELISA Kit; NRG4_HUMAN ELISA Kit; pro-neuregulin-4; membrane-bound isoform ELISA Kit; Pro-NRG4 ELISA Kit

Abbreviation

NRG4

Uniprot No.

Q8WWG1

Species

Homo sapiens (Human)

Sample Types

serum, plasma, tissue homogenates

Detection Range

125 pg/mL-8000 pg/mL

Sensitivity

31.25 pg/mL

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Neuroscience

Assay Principle

quantitative

Measurement

Sandwich

Precision

Linearity

To assess the linearity of the assay, samples were spiked with high concentrations of human NRG4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	90
	Range %	86-95
1:2	Average %	97
	Range %	91-105
1:4	Average %	95
	Range %	90-101
1:8	Average %	85
	Range %	82-89

Recovery

The recovery of human NRG4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	90	87-96
EDTA plasma (n=4)	98	94-103

Typical Data

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
8000	2.335	2.256	2.296	2.102
4000	1.648	1.768	1.708	1.514
2000	1.191	1.201	1.196	1.002
1000	0.812	0.823	0.818	0.624
500	0.588	0.596	0.592	0.398
250	0.475	0.484	0.480	0.286
125	0.367	0.381	0.374	0.180
0	0.193	0.195	0.194

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Lead Time

7-14 working days

Alteration of serum neuregulin 4 and neuregulin 1 in gestational diabetes mellitus L Zhang,Therapeutic advances in endocrinology and metabolism,2021
Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease? TJI De Munc,PloS one,2021
Clinical Importance of Neuregulin‐4 and Its Receptor ErbB4 in Periodontal Disease Pathogenesis B Meraci,Oral Diseases,2020

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Function (From Uniprot)	Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Gene References into Functions	Nrg4 is highly and preferentially expressed in healthy adipocytes, while its expression was substantially reduced in obesity. Nrg4 activated endothelial angiogenic functions and angiogenesis both in vitro and in vivo. PMID: 29902456 Serum NRG4 values were significantly elevated in the Gestational Diabetes Mellitus (GDM) group compared to the control group and is associated with metabolic parameters of GDM. PMID: 29282998 circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults; circulating Nrg4 might play a role in identifying patients at high risk for cardiovascular disease PMID: 27819316 The circulating Nrg4 level is elevated in the prediabetic and diabetic patients compared to control and is an independent risk factor associated with diabetes. PMID: 27862843 High serum Nrg4 levels are associated with type 2 diabetes mellitus. PMID: 27329015 NRG4 and its receptor ErbB4 are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 signaling may be a novel pathway for therapeutic intervention or prevention in NEC. PMID: 25216938 Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD). PMID: 26476959 results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). PMID: 25401691 Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival PMID: 23033483 The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4. PMID: 21805036 NRG4 overexpression is associated with advanced-stage prostate cancer PMID: 17545517 describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide PMID: 17684490 NRG4 was positive in almost all breast cancers studied. PMID: 17962208 Neuregulin-4 expression is downregulated during urinary bladder cancer progression PMID: 15583696 Show More Hide All
Subcellular Location	Pro-neuregulin-4, membrane-bound isoform: Cell membrane, Single-pass type I membrane protein
Protein Families	Neuregulin family
Database Links	HGNC: 29862 OMIM: 610894 KEGG: hsa:145957 STRING: 9606.ENSP00000378367 UniGene: Hs.732438

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The Overview of One Category of Important Cell Receptors: Receptor Tyrosine Kinases ELISA Data Analysis How to Do The Pre-experiment before Your ELISA Experiment Four Types of ELISA 11 tips for choosing your right ELISA kit Do you Often Trouble in These Problems of ELISA? Problems and Solutions in ELISA Experiments

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ErbB signaling pathway

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Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.

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