Human osteocrin,Ostn ELISA kit

Code CSB-E12021h
Size 96T,5×96T,10×96T
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Product Details

Target Name
Alternative Names
OSTN ELISA Kit; Osteocrin ELISA Kit; Musclin) [Cleaved into: Processed Osteocrin] ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.312 ng/mL-20 ng/mL
0.078 ng/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Stem Cells
Assay Principle
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
To assess the linearity of the assay, samples were spiked with high concentrations of human Ostn in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
1:1Average %87
Range %82-92
1:2Average %99
Range %94-103
1:4Average %96
Range %92-99
1:8Average %95
Range %88-98
The recovery of human Ostn spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9489-97
EDTA plasma (n=4)9791-99
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
202.552 2.699 2.626 2.510
102.254 2.373 2.314 2.198
51.804 1.928 1.866 1.750
2.50.889 0.926 0.908 0.792
1.250.517 0.498 0.508 0.392
0.6250.320 0.304 0.312 0.196
0.3120.216 0.202 0.209 0.093
00.118 0.114 0.116  
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Human OSTN ELISA Kit was designed for the quantitative measurement of Human OSTN protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 0.312 ng/mL-20 ng/mL and the sensitivity is 0.078 ng/mL .

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Target Background

(From Uniprot)
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex. Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production.
Gene References into Functions
  1. The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus. PMID: 28185530
  2. findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates PMID: 27830782
  3. osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator PMID: 14523025
  4. Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells. PMID: 17950246
  5. Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. PMID: 17951249
  6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19453261

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Subcellular Location
Protein Families
Osteocrin family
Tissue Specificity
Enriched in neocortical regions of the developing cerebral cortex. Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum. Also expressed in bon
Database Links

HGNC: 29961

OMIM: 610280

KEGG: hsa:344901

STRING: 9606.ENSP00000342356

UniGene: Hs.526794

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