Oxidized low-density lipoprotein antibodies represent an important class of autoantibodies that develop in response to oxidatively modified LDL particles. When LDL undergoes oxidative modification, it creates neo-epitopes that the immune system recognizes as foreign. The presence of ox-LDL antibodies has been studied extensively in cardiovascular research. They serve as biomarkers reflecting both oxidative stress and immune responses to modified lipoproteins in atherosclerotic processes.
The Human oxidized low density lipoprotein antibody ELISA Kit (CSB-E08797h) provides quantitative measurement of ox-LDL Ab in human serum and plasma samples using a sandwich assay principle. The kit offers a detection range of 47 μU/mL to 3000 μU/mL with a sensitivity of 11.75 μU/mL. The assay requires 50-100 μL sample volume and can be completed within 1-5 hours, with detection performed at 450 nm wavelength.
Application Examples
Note: The following application examples are drawn from a selection of publications citing this product. For additional applications, please refer to the full list of references in the "Citations" section.
This ELISA kit has been used in research investigating oxidative stress and antioxidant defense mechanisms in various physiological contexts. Studies have used the kit to measure oxidized low-density lipoprotein antibody levels in serum samples as part of comprehensive antioxidant status evaluations. The kit supports research examining the relationship between oxidative biomarkers and metabolic health parameters.
• Antioxidant defense research: Measuring oxidized LDL antibody titers alongside other antioxidant markers including superoxide dismutase activity, glutathione levels, and ferric reducing antioxidant power to evaluate overall antioxidant status
• Oxidative stress evaluation: Measuring oxidized LDL antibodies in serum samples to investigate oxidative stress responses and antioxidant mechanisms in human subjects
• Metabolic biomarker studies: Integration with inflammatory marker analysis to examine relationships between oxidative stress indicators and metabolic health parameters in clinical research settings
