Human vascular endothelial cell growth factor receptor 1 (VEGFR-1/Flt1) ELISA kit

1. these results indicate that sFlt-1 up-regulation by VEGF may be mediated by the VEGF/Flt-1 and/or VEGF/KDR signaling pathways. PMID: 29497919
2. Serum sFlt-1 can be used as a prognostic marker to predict the occurrence of complications of preeclampsia. PMID: 30032672
3. The ratio of sFlt-1/sEGFR could be used as a novel candidate biochemical marker in monitoring the severity of preterm preeclampsia. sEndoglin and sEGFR may be involved in the pathogenesis of small for gestational age in preterm preelampsia. PMID: 30177039
4. A contingent strategy of measuring the sFlt-1/PlGF ratio at 24-28weeks in women previously selected by clinical factors and uterine artery Doppler enables an accurate prediction of preeclampsia/fetal growth restriction. PMID: 30177066
5. dynamic regulation of mVEGFR1 stability and turnover in blood vessels impacts angiogenesis PMID: 28589930
6. Study shows that soluble VEGF receptor 1 (sVEGFR-1/ soluble fms-like tyrosine kinase 1 [sFlt-1]) showed a cytotoxic effect on BeWo cells. Results suggest that sFLT-1 could be therapeutic for malignant tumors. PMID: 28322131
7. A single measurement of sFlt-1/PlGF ratio at third trimester to predict pre-eclampsia and intrauterine growth retardation occurring after 34weeks of pregnancy. PMID: 29674192
8. sFlt1 was produced in significant amounts by preeclamptic peripheral blood mononuclear leukocytes, and ex vivo studies show that the placenta induces this over-expression. In contrast, exposure to PBMCs appears to decrease sFlt1 production by preeclamptic placenta. PMID: 29674197
9. The levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in pre-eclamptic women with an onset at < 32 weeks were sig- ni fi cantly di ff erent from those in women with an onset at >/=32-33 weeks. PMID: 29674208
10. These results showed that arginase controlled sFlt-1 elevation to some extent. PMID: 29548823
11. These results suggest that VM formation is increased by EBVLMP1 via VEGF/VEGFR1 signaling and provide additional information to clarify the role of EBVLMP1 in nasopharyngeal carcinoma (NPC)pathophysiology PMID: 29749553
12. An sFlt-1:PlGF ratio above 655 is not predictive of impaired perinatal outcomes, and insufficiently reliable for predicting outcomes in cases with clinical signs of preeclampsia. PMID: 29523274
13. The maternal sFlt-1 to PlGF ratio in women with hypertensive disorders in pregnancy carries prognostic value for the development of preeclampsia. PMID: 29523275
14. VEGFA activates VEGFR1 homodimers and AKT, leading to a cytoprotective response, whilst abluminal VEGFA induces vascular leakage via VEGFR2 homodimers and p38 PMID: 29734754
15. metformin's dual effect in hyperglycemia-chemical hypoxia is mediated by direct effect on VEGFR1/R2 leading to activation of cell migration through MMP16 and ROCK1 upregulation, and inhibition of apoptosis by increase in phospho-ERK1/2 and FABP4, components of VEGF signaling cascades PMID: 29351188
16. Additionally, LVsFlt1MSCs inhibited tumor growth and prolonged survival in an hepatocellular carcinoma (HCC)mouse model via systemic injection. Overall, the present study was designed to investigate the potential of LVsFlt1MSCs for antiangiogenesis gene therapy in HCC. PMID: 28849176
17. Review of the role of dysregulation at the Fms-like tyrosine kinase 1 locus in the fetal genome (likely in the placenta) in conferring genetic predisposition to preeclampsia. PMID: 29138037
18. VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae. PMID: 28770473
19. High PlGF and/or low sFlt-1/PlGF may be used to diagnose Peripartum Cardiomyopathy. PMID: 28552862
20. Results demonstrate that short-activating RNA targeting the flt-1 promoter increased sFlt-1 mRNA and protein levels, while reducing VEGF expression. This was associated with suppression of human umbilical vascular endothelial cell (HUVEC) proliferation and cell cycle arrest at the G0/G1 phase. HUVEC migration and tube formation were also suppressed by Flt a-1. PMID: 29509796
21. In this context, our results demonstrate that D16F7 markedly inhibits chemotaxis and invasiveness of GBM cells and patient-derived GBM stem cells (GSCs) in response to VEGF-A and PlGF, suggesting that VEGFR-1 might represent a suitable target that deserves further investigation for GBM treatment. PMID: 28797294
22. Study showed that term deliveries, higher soluble fms-like tyrosine kinase 1 (sFlt1) concentrations were associated with a smaller uterine artery resistance indices (RI) at the subsequent visit. For preterm delivery, higher sFlt1 concentrations were associated with a larger uterine artery RI. PMID: 28335685
23. elevated in preeclampsia and fetal growth restriction PMID: 27865093
24. Studied serum levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) as markers for early diagnosis of preeclampsia. PMID: 29267975
25. This prospective observational study compare urine nephrin:creatinine ratio (NCR, ng/mg) with serum soluble fms-like tyrosine kinase-1:placental growth factor ratio (FPR, pg/pg) for preeclampsia (PE) prediction among unselected asymptomatic pregnant women in 2(nd) trimester. PMID: 27874074
26. A high sFlt-1/PlGF ratio was associated with adverse outcomes and a shorter duration to delivery in early-onset fetal growth restriction. PMID: 28737473
27. Serum from type 2 diabetics reduced Akt/VEGFR-1 protein expression in endothelial progenitor cells. PMID: 28732797
28. The VEGF/sVEGF-R1 ratio in follicular fluid on the day of oocyte retrieval in women undergoing IVF procedure, regardless of the type of stimulation protocol, might predict the risk of developing ovarian hyperstimulation syndrome (OHSS). To the best of our knowledge this is the first paper in the literature to show interplay among VEGF, EG-VEGF and sVEGF-R1 and the correlation between their concentration and OHSS risk. PMID: 28820403
29. plasma level not associated with placenta size PMID: 28613009
30. the difference between the pro- (VEGF165a) and antiangiogenic (VEGF165b) VEGF isoforms and its soluble receptors for severity of diabetic retinopathy, is reported. PMID: 28680264
31. detectable amounts are produced by endometrial stromal cells (ESC)); expression is turned off during decidualization; ESC decidualization and resulting sFlt1 expression are a reversible phenomenon PMID: 28494174
32. High sFlt-1 concentrations may account for diminished maternal serum PlGF levels. PMID: 28494189
33. upregulated tenfold in preeclamptic tissue PMID: 28067578
34. upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in preeclampsia compared to normotensive pregnancies, Irrespective of the HIV status PMID: 28609170
35. In patients with hypertensive disorders of pregnancy, those in the highest tertile of mean arterial pressure had the highest serum levels of sFlt1 and sEng. PMID: 28609171
36. likely that in early onset pre-eclampsia, increased maternal sFlt-1 concentrations are the primary reason for diminished maternal serum-free PlGF levels PMID: 28609172
37. Based on these data, we conclude that the rs9943922 SNP in the FLT1 gene does not result in a large difference in FLT1 protein levels, regardless of whether it is the soluble or the membrane bound form. PMID: 28949775
38. Report sensitivity of sFlt-1/PlGF ratio for diagnosis of preeclampsia and fetal growth restriction. PMID: 28501276
39. Our study suggests that "migration" of the placenta is derived from placental degeneration at the caudal part of the placenta, and sFlt-1 plays a role in this placental degeneration. PMID: 29409879
40. the association of VEGFR1 rs9582036 and rs9554320 with the outcome of sunitinib in mRCC patients did not reach the threshold for statistical significance, and therefore, both genetic variants have limited use as biomarkers for prediction of sunitinib efficacy. PMID: 27901483
41. Placental sFLT-1 expression is upregulated in approximately 28% of non-preeclamptic pregnancies complicated by small for gestational age infants. These pregnancies showed increased placental vascular pathology, more umbilical Doppler abnormalities, and earlier delivery with lower birthweight PMID: 28454690
42. This study demonstrated that the baseline of sFlt-1 was significantly correlated with soft neurologic signs and right entorhinal volume but not other baseline clinical/brain structural measures in patient with psychosis. PMID: 27863935
43. By comparing in vivo data with immunohistochemical analysis of excised tumors we found an inverse correlation between 99mTc-VEGF165 uptake and VEGF histologically detected, but a positive correlation with VEGF receptor expression (VEGFR1). PMID: 28498441
44. sFLT-1 represents a link between angiogenesis, endothelial dysfunction, and subclinical atherosclerosis. Measurement of sFLT-1 as a marker of vascular dysfunction in beta-TI may provide utility for early identification of patients at increased risk of cardiopulmonary complications. PMID: 28301910
45. Icrucumab and ramucirumab are recombinant human IgG1 monoclonal antibodies that bind vascular endothelial growth factor (VEGF) receptors 1 and 2 (VEGFR-1 and -2), respectively. VEGFR-1 activation on endothelial and tumor cell surfaces increases tumor vascularization and growth and supports tumor growth via multiple mechanisms, including contributions to angiogenesis and direct promotion of cancer cell proliferation. PMID: 28220020
46. sFLT-1 e15a splice variant is seen only in humans and is principally expressed in the placenta, making it likely to be the variant chiefly responsible for the clinical features of early-onset pre-eclampsia. (Review) PMID: 27986932
47. significant reduction in sVEGFR-1 levels after renal denervation procedure for hypertension PMID: 27604660
48. Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8(+) T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2. VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis PMID: 27401249
49. Circulating tissue transglutaminase is associated with sFlt-1, soluble endoglin and VEGF in the maternal circulation of preeclampsia patients, suggesting that tTG may have a role in the pathogenesis of PE. PMID: 27169826
50. The authors observed direct damage caused by sFLT1 in tumour cells. They exposed several kinds of cells derived from ovarian and colorectal cancers as well as HEK293T cells to sFLT1 in two ways, transfection and exogenous application. The cell morphology and an lactate dehydrogenase assay revealed cytotoxicity. PMID: 27103202
51. Altered antiangiogenic state because of altered circulating sFlt1 leads to Preeclampsia, ratio of sFlt1/PlGF correlates with Preeclampsia phenotypes. PMID: 27067718
52. Gestation-adjusted sEng, sFlt-1 and PlGF levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies PMID: 27664209
53. the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (40.2pg/mL), VEGF-A (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (248.1pg/mL), sHER-2/neu (5010pg/mL) and PLGF (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported. PMID: 27599390
54. Results indicate that miR-507 represented potential therapeutic targets in breast cancer by modulating fms-related tyrosine kinase-1 (Flt-1). PMID: 27167339
55. VEGF-Flt-1 signaling induces osteoclastogenesis in OSCC through two possible ways: 1) VEGF produced from OSCC cells can directly stimulate the Flt-1 pathway in preosteoclasts to induce migration to future bone resorbing area and differentiation into osteoclasts, and 2) VEGF-Flt-1 signaling upregulates RANKL expression in OSCC cells, which indirectly leads to osteoclast differentiation PMID: 29149180
56. Study demonstrates that placental-specific overexpression of hsFlt-1 alters placental morphology and trophoblast differentiation and interferes with IGF2 and nutrient transporter expression leading to intrauterine growth restriction. PMID: 27859593
57. this study found no difference in VEGFR1 expression in infantile hemangiomas from the study and control group PMID: 27178307
58. MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2 PMID: 28358369
59. The SNPs rs9554322, rs9582036 and rs9943922 were correlated with age-related macular degeneration (AMD). Gene variants in VEGFR1 were linked to a pronounced emerging risk for AMD in a population in northern China. PMID: 26914796
60. Leptin-induced transphosphorylation of vascular endothelial growth factor receptor increases Notch and stimulates endothelial cell angiogenic transformation PMID: 27590851
61. The study aimed to assess the usefulness of the determination of cytokines: IL-8, VEGF and its soluble receptors: VEGF-R1, VEGF-R2 in patients with endometrial cancer. The concentrations of IL-8, VEGF, VEGFR1 and CA 125 allowed to distinguish patients for the control group. PMID: 28991928
62. Gestational diabetes mellitus is associated with reduced expression of Flt-1 mRNA and protein. PMID: 28817576
63. Structure of the full-length VEGFR-1 extracellular domain in complex with VEGF-A has been reported. PMID: 28111021
64. Results show that both FLT1 and PGF are overexpressed in the circulating tumor cells (CTCs) of patients with breast cancer. Also, a functional interaction of sFlt1 and PGF was found, suggesting that their overexpression in tumor cells inhibits CTCs entering the peripheral blood. PMID: 27464822
65. variants near FLT1 may modulate preeclampsia susceptibility PMID: 28628106
66. Flt1 has a role in blood vessel anastomosis during angiogenesis PMID: 28246215
67. variants rs35832528 (E982A; P=2.49E-4; odds ratio=0.387) and rs141440705 (R54S; P=0.003; odds ratio=0.442) in Fms related tyrosine kinase 1 significantly associated with maternal protective genetic variants in Preeclampsia in the Finnish Population. PMID: 28652462
68. Serum and urinary sFlt-1 and sFlt-1/PLGF ratios in severe preeclampsia patients were significantly higher than those in the mild preeclampsia group, and measurements from mild preeclampsia patients were significantly higher than controls PMID: 27834501
69. FLT-1 rs7324510 C/A variant may be a new genetic risk factor for severity of rheumatoid arthritis. Examined factor highly predispose to more severe disease activity as well as higher sFLT-1 levels in rheumatoid arthritis. PMID: 28323906
70. Molecular dynamics simulations of VEGFR-1 Wt and (p.Cys1110Ser) variant revealed exposure of the activation domain increasing the probability of phosphorylation events: a condition frequently reported in cancers. PMID: 27049304
71. The normalized methylation values for the VEGFR1, VEGFR2 and VEGFR3 promoters tended to be higher in the tumour cell lines than in normal tonsil samples, whereas amounts of VEGFR1, VEGFR2 and VEGFR3 messenger RNA were significantly higher PMID: 28718364
72. Both the TNF-alpha/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset Preeclampsia (PE) than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE PMID: 27315098
73. this study shows that Fli-1 plays a major role in the regulation of granulocyte colony stimulating factor PMID: 27431361
74. Patients with post-peripartum cardiomyopathy have significantly higher plasma sFlt1 concentration with a trend of somewhat higher levels of VEGF and significantly decreased VEGF/sFlt1 ratio compared to controls. PMID: 28029641
75. soluble fms-like tyrosine kinase-1 inhibits cell proliferation, migration, and invasion of colorectal cancer SW480 cells through suppression of vascular mimicry formation, which provides a good basis for the development of new drugs for the treatment of colorectal cancer by targeting both angiogenesis and vascular mimicry formation. PMID: 28468595
76. a significant association between the expanded disability status scale and sVEGFR1 (beta=0.007; p<0.001). Our findings revealed that circulatory membranous as well as soluble expression of VEGFR1 increases during angiogenic and inflammatory phenomena of MS. PMID: 27424135
77. Data suggest that the associations among angiopoietin-2, sFlt-1, coagulation abnormalities and severe course of acute pancreatitis (AP) might be mediated by other bioactive compounds. PMID: 28368336
78. The preeclampsia group had higher soluble fms-like tyrosine kinase-1 from >/=28 weeks compared to controls. PMID: 27793555
79. A strong, novel prospective association was identified between lower concentrations of soluble Fms-like kinase 1 and placental growth factor measured in early pregnancy and spontaneous abortion. PMID: 27287686
80. Women with preeclampsia had higher concentrations of soluble Fms-like tyrosine kinase 1 compared with control subjects. There were significant uteroplacental arteriovenous differences of soluble Fms-like tyrosine kinase 1 in preeclampsia, but not in the control subjects. PMID: 27503620
81. The rs9508025 in FLT1 was significantly associated with long-term cardiovascular events, particularly in patients with prior coronary artery disease. PMID: 27736948
82. VEGFR1 rs9582036 is a candidate predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib. PMID: 27417418
83. our data demonstrate an association of higher levels of sFLT-1 with increased expression of miR-195-5p in preeclampsia pregnant women. PMID: 26910493
84. membranebound VEGFR1 is frequently expressed in normal and cancerous breast epithelium. In addition, reduced or lost VEGFR1 expression may serve as a marker for poor prognosis in patients with breast cancer, who might not optimally benefit from endocrine therapy. PMID: 27357606
85. These studies identify uPA-dependent de-repression of vegfr1 and vegfr2 gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA mediates the pro-angiogenic effects of VEGF and identifies a potential new target for control of pathologic angiogenesis. PMID: 27151212
86. This study aimed to analyze the ultrastructure and histomorphometric changes of the human umbilical cord vessels of preeclampsia compared to healthy pregnancies and the possible role of vascular endothelial growth factor (VEGF) and its receptors. PMID: 27833959
87. Our results indicate that the genetically coded increased expression of FLT1 by a functional SNP implicates activation in an inflammatory cascade that might eventually lead to CAD. PMID: 26791355
88. sFlt-1 concentrations in saliva and gingival crevicular fluid were significantly higher in patients with pre-eclampsia. PMID: 26988336
89. Flt-1 blood levels are increased in women who developed early- or late-onset preeclampsia. PMID: 27983995
90. serum level associated with severity of gestational hypertension and pre-eclampsia PMID: 28121958
91. CAIX and PTEN had prognostic importance for metastatic renal cell carcinoma patients receiving first-line VEGFR TKI. Future validation and mechanistic studies are required. PMID: 26526582
92. Underexpression of FLT1 is associated with HPV-positive head and neck cancers. PMID: 26666815
93. Studies indicate that natural products have shown efficacy and noted to be exert tumor suppressive effects via inhibition of VEGF and VEGFR both at mRNA and protein level. PMID: 28145862
94. A uterine curettage may slightly accelerate the fall of the postpartal sFlt-1 concentration. The previously described benefit of curettage in patients with preeclampsia regarding faster recovery or treatment of postpartum seizures may be partly explained as mediated by anti-angiogenic factors. PMID: 26352069
95. sFLT1 is able to form a heterodimer with cell surface VEGF receptors and is therefore able to have a dominant negative effect (in addition to acting as a competitive inhibitor by simply binding vascular endothelial growth factor A [VEGFA] and placental growth factor [PlGF]). This leads in vitro to the sensitisation of endothelial cells to low levels of TNFalpha. PMID: 26228018
96. angiogenesis regulators VEGF-R2 and VEGF-A but not VEGF-R1 have association with the p53 status with regard to recurrent disease and survival PMID: 26783205
97. These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia. PMID: 26819475
98. VEGFR1 rs722503 is associated with preeclampsia occurring at or after the age of 40 years. PMID: 27668980
99. sFlt played important role in megakaryocytopoesis and platelet homeostasis in preterm infants born to mothers with preeclampsia. PMID: 26083681
100. Findings indicate that hnRNP D and arginine methylation play important roles in the regulation of Flt-1 mRNA alternative polyadenylation. PMID: 26728997

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HGNC: 3763

OMIM: 165070

KEGG: hsa:2321

STRING: 9606.ENSP00000282397

UniGene: Hs.594454