Code | CSB-RA940669A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:2000 |
IHC | 1:50-1:200 |
FC | 1:50-1:200 |
The FLT1 recombinant monoclonal antibody is generated through in vitro processes using synthetic genes. This methodology involves the retrieval of FLT1 antibody genes from B cells sourced from immunoreactive rabbits, followed by their amplification and cloning into appropriate phage vectors. These vectors are then introduced into mammalian cell lines, enabling the production of functional antibodies in substantial quantities. Subsequently, the FLT1 recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography. It is well-suited for a wide range of applications, including ELISA, WB, IHC, and FC, facilitating the precise detection of human and mouse FLT1 proteins.
FLT1, also known as VEGFR-1, is to serve as a receptor for VEGF and PlGF. Upon binding to its ligands, FLT1 initiates intracellular signaling pathways that are crucial for angiogenesis, the process of forming new blood vessels. By transducing these signals, FLT1 plays a pivotal role in regulating vascular development, endothelial cell proliferation, migration, and survival, ultimately influencing processes like wound healing, embryonic development, and pathological conditions such as tumor angiogenesis.
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