Mouse A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAMTS4) ELISA kit

Code CSB-EL001311MO
Size 96T,5×96T,10×96T
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Product Details

Target Name
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Alternative Names
Adamts4A disintegrin and metalloproteinase with thrombospondin motifs 4 ELISA kit; ADAM-TS 4 ELISA kit; ADAM-TS4 ELISA kit; ADAMTS-4 ELISA kit; EC 3.4.24.82 ELISA kit; Aggrecanase-1 ELISA kit
Abbreviation
ADAMTS4
Uniprot No.
Species
Mus musculus (Mouse)
Sample Types
serum, plasma, tissue homogenates
Detection Range
3.12 ng/mL-200 ng/ mL
Sensitivity
0.78 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Cell Biology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

Function
(From Uniprot)
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Gene References into Functions
  1. host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. PMID: 29926003
  2. This study demonstrated that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities. PMID: 28850711
  3. results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE(-/-) mice PMID: 27491335
  4. the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues PMID: 26809777
  5. aggrecan and brevican proteolysis is compensated in Adamts4-/- or Adamts5-/- mice by ADAMTS proteoglycanase family members but a threshold of versican proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase during spinal cord injury PMID: 25101296
  6. ADAMTS4 has roles in melanoma growth and angiogenesis in mice PMID: 23319426
  7. The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes. PMID: 23082219
  8. ADAMTS-4 cleaves Reelin in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 cleaves the N-t site only, while p75 cleaves both sites. PMID: 22819337
  9. Data demonstrate that Adamts1 and Adamts4 play redundant and essential roles in perinatal kidney development. PMID: 21584905
  10. Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae. PMID: 20448247
  11. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue PMID: 20018883
  12. ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns that relate to the expression pattern of versican in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary. PMID: 15659705
  13. ADAMTS-5 is entirely responsible for cleavage in the interglobular domain, but cleavage in the chondroitin sulfate-rich region may be driven by ADAMTS-4 PMID: 17255106
  14. comparison of aggrecan loss with aggrecan processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat) PMID: 17938173
  15. Deletion of ADAMTS-4/5 provided significant protection against proteoglycan degradation ex vivo and decreased the severity of murine osteoarthritis PMID: 17968948

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
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