ADAMTS13 is a zinc metalloprotease that plays an important role in hemostasis by cleaving von Willebrand factor (vWF) multimers. This enzyme regulates the size and activity of vWF, preventing excessive platelet aggregation and thrombosis. Deficiency or dysfunction of ADAMTS13 is associated with thrombotic thrombocytopenic purpura (TTP), a rare but life-threatening condition characterized by microangiopathic hemolytic anemia and thrombocytopenia. Research into ADAMTS13 activity and regulation is essential for understanding vascular biology and developing therapeutic approaches for thrombotic disorders.
The Mouse ADAMTS13 ELISA kit (CSB-EL001301MO) is a quantitative sandwich assay designed for measuring ADAMTS13 levels in Mus musculus samples. This kit works with serum, plasma, and tissue homogenates with a detection range of 78 pg/mL to 5000 pg/mL and sensitivity of 19.5 pg/mL. The assay requires 50-100 μL sample volume and can be completed within 1-5 hours. Detection occurs at 450 nm wavelength, providing researchers with a reliable tool for ADAMTS13 quantification in mouse studies.
Application Examples
Note: The following application examples are drawn from a selection of publications citing this product. For additional applications, please refer to the full list of references in the "Citations" section.
This ELISA kit has been used in research studying vascular biology and hemostatic mechanisms, particularly in studies examining the balance between blood coagulation and fibrinolysis. The kit allows quantitative measurement of ADAMTS13 in mouse plasma samples, supporting studies of thrombotic and vascular pathophysiology.
• Vascular research: Applied in studies examining endothelial cell function and vascular adhesion mechanisms alongside other vascular markers
• Hemostatic studies: Used to measure ADAMTS13 levels in plasma samples as part of comprehensive coagulation and fibrinolysis profiling
• Biomarker profiling: Applied in multi-analyte panels to evaluate cytokine and protein expression patterns in experimental models
• Thrombotic disease research: Used in studies of blood clotting disorders and related vascular pathologies
