Mouse Beta-klotho(KLB) ELISA kit

1. Downregulation of beta-klotho expression is not the major mechanism of impaired FGF21 signaling in white adipose tissue. PMID: 28580290
2. liver FGF21-betaKlotho pathway sufficient and necessary to repress mTOR/S6K activity PMID: 26926384
3. The study supports a pro-adipogenic role for betaKlotho in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR-betaKlotho axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy. PMID: 26881702
4. Data show that enhancing beta-klotho (KLB) expression in adipose may sensitize to endogenous fibroblast growth factor 21 (FGF21), thus representing a novel strategy to combat metabolic disease. PMID: 26901091
5. beta-Kl in hepatocytes is necessary and sufficient for lipid homeostasis, whereas nonhepatic beta-Kl regulates energy metabolism. PMID: 26514166
6. ATF4 signaling pathway is essential for mediating the effect of ER stress on beta-klotho expression. PMID: 25727012
7. Klotho is a novel player in the retina, with a clear connection to photoreceptor cell death as well as with an influence on retinal organization. PMID: 23796581
8. Mice lacking the FGF21 co-receptor, beta-Klotho, in the suprachiasmatic nucleus are refractory to the inhibitory effect of FGF21 on female fertility. PMID: 23933983
9. The effects of FGF21 are mediated through beta-Klotho expression in the suprachiasmatic nucleus of the hypothalamus and the dorsal vagal complex of the hindbrain. PMID: 23933984
10. betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. PMID: 22958921
11. demonstrate the first manifest evidence revealing that whereas alpha-Kl and beta-Kl are required for FGF23 and FGF15/hFGF19-mediated signaling pathways in vivo, respectively, beta-Kl appears not to be essential for FGF21-mediated signal transduction in vivo. PMID: 20080590
12. KLB and FGFR1 form a 1:1 heterocomplex independent of the galectin lattice that transitions to a 1:2 complex upon the addition of FGF21. PMID: 22523080
13. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PMID: 22442730
14. In contrast to wild-type FGF23, FGF23-21c (a variant of FGF23 where the C-terminal domain of FGF23 was replaced with the corresponding regions from FGF21), FGF23-21c gained the ability to activate FGFR1c and FGFR2c in the presence of betaKlotho. PMID: 22370560
15. function of Klotho family proteins PMID: 22396160
16. These results indicate that betaKlotho and FGFRs form the cognate FGF-21 receptor complex, mediating FGF-21 cellular specificity and physiological effects. PMID: 18064602
17. Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. PMID: 20657013
18. betaKlotho functions as a cofactor essential for fibroblast growth factor 21 activity PMID: 17452648
19. Data suggested that betaKlotho expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion. PMID: 18187602
20. The results of this study indicate that both beta-Klotho and FGF-15/19 repress the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. PMID: 18772362

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KEGG: mmu:83379

STRING: 10090.ENSMUSP00000031096

UniGene: Mm.45274