Insulin-like growth factor binding protein acid labile subunit (IGFALS) is a key component of the ternary complex that regulates IGF bioavailability and transport in circulation. This glycoprotein forms stable complexes with IGF-binding proteins and IGFs, extending the half-life of circulating IGFs and modulating their biological activity. IGFALS plays a central role in growth regulation, metabolic homeostasis, and cellular proliferation. It serves as an important biomarker for studying growth disorders and metabolic diseases in research applications.
The Mouse Insulin-like growth factor-binding protein complex acid labile subunit ELISA kit (CSB-EL011094MO) provides quantitative measurement of IGFALS in Mus musculus samples. This sandwich ELISA works with serum, plasma, and tissue homogenates. The detection range spans 3.12-200 ng/mL with sensitivity of 0.78 ng/mL. The assay requires 50-100 μL sample volume, completes within 1-5 hours, and uses detection at 450 nm wavelength for reliable quantification of mouse IGFALS levels.
Application Examples
Note: The following application examples are drawn from a selection of publications citing this product. For additional applications, please refer to the full list of references in the "Citations" section.
This ELISA kit has been used in research examining the insulin-like growth factor system and its regulatory components in mouse models. Studies have applied the kit to measure serum levels of the acid labile subunit as part of comprehensive endocrine profiling alongside other growth-related factors. The kit supports research examining the complex interactions between growth hormone signaling pathways and metabolic regulation.
• Endocrine research: Analysis of growth hormone axis components in serum samples from mouse models to understand hormonal regulation and signaling pathways
• Metabolic studies: Examination of insulin-like growth factor binding protein complex dynamics in conjunction with growth hormone and related binding proteins
• Biomarker profiling: Quantification of acid labile subunit levels as part of multi-analyte panels examining growth factor system components and their molar relationships
