Mouse Interleukin-22 receptor subunit alpha-2(IL22RA2) ELISA kit

Code CSB-EL011637MO
Size 96T,5×96T,10×96T
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Product Details

Target Name
interleukin 22 receptor, alpha 2
Alternative Names
Il22ra2Interleukin-22 receptor subunit alpha-2 ELISA Kit; IL-22 receptor subunit alpha-2 ELISA Kit; IL-22R-alpha-2 ELISA Kit; IL-22RA2 ELISA Kit; Cytokine receptor family type 2 ELISA Kit; soluble 1 ELISA Kit; CRF2-S1 ELISA Kit; Interleukin-22-binding protein ELISA Kit; IL-22BP ELISA Kit; IL22BP ELISA Kit; ZcytoR16 ELISA Kit
Abbreviation
IL22RA2
Uniprot No.
Species
Mus musculus (Mouse)
Sample Types
serum, plasma, tissue homogenates
Detection Range
46.88 pg/mL-3000 pg/mL
Sensitivity
11.7 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of mouse IL22RA2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
 SampleSerum(n=4)
1:1Average %94
Range %90-97
1:2Average %100
Range %95-103
1:4Average %95
Range %89-100
1:8Average %89
Range %84-92
Recovery
The recovery of mouse IL22RA2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9590-97
EDTA plasma (n=4)9591-98
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pg/mlOD1OD2AverageCorrected
30002.412 2.423 2.418 2.258
15001.812 1.776 1.794 1.634
7501.116 1.078 1.097 0.937
3750.705 0.688 0.697 0.537
187.50.434 0.459 0.447 0.287
93.750.322 0.314 0.318 0.158
46.880.256 0.243 0.250 0.090
00.162 0.158 0.160  
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Mouse IL22RA2 ELISA Kit was designed for the quantitative measurement of Mouse IL22RA2 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 46.88 pg/mL-3000 pg/mL and the sensitivity is 11.7 pg/mL .

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Target Background

Function
(From Uniprot)
Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Gene References into Functions
  1. limits the pathological manifestations in models of allergic contact dermatitis and psoriasis PMID: 27676439
  2. Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression. PMID: 29109123
  3. IL-22BP promotes bacterial uptake into Peyer's patches by influencing follicle-associated epithelium gene expression and function. PMID: 28512157
  4. IL22RA2 KO displayed a less severe EAE course, less demyelination and less infiltration of immune cells in the CNS. PMID: 25008863
  5. the IL-22-IL-22BP axis critically regulates intestinal tissue repair and tumorigenesis in the colon PMID: 23075849
  6. cloning and characterization; gene encodes a protein of 230 amino acids that share 67.1% amino-acid sequence identity with human IL-22 binding protein; upregulated by LPS stimulation in monocytes PMID: 12700595

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Subcellular Location
Secreted.
Protein Families
Type II cytokine receptor family
Tissue Specificity
Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
Database Links
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