Mouse Vascular Endothelial cell Growth Factor B,VEGF-B ELISA kit

1. VEGF-B is a potent regulator of the antioxidant pathway in retina.The antioxidant function of VEGF-B is mediated mainly by VEGFR1. PMID: 30249667
2. the expression and role of VEGF-B in diabetic corneal neuropathy was examined by using type 1 diabetic mice and cultured trigeminal ganglion (TG) neurons. PMID: 28091556
3. Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue. PMID: 26707994
4. renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease. PMID: 28190774
5. PGC-1alpha is a master metabolic sensor that regulates the expression of Vegfa and Vegfb, coordinates blood vessels growth and fatty acid uptake with mitochondrial fatty acid oxidation. PMID: 26822083
6. These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B to VEGFR1. PMID: 26928042
7. VEGFB-Induced Vascular Remodeling in Adipose Tissue Requires VEGF/VEGFR2. VEGFB-Induced Vascular Remodeling Improves Insulin Supply, Signaling, and Function in Obese Mice. PMID: 27076080
8. VEGF-B is dispensable for normal cardiac function under unstressed conditions and for high fat diet-induced metabolic changes. PMID: 25168313
9. VEGF-B is a vascular remodeling factor promoting cancer metastasis. PMID: 25991856
10. Data indicate that vascular endothelial growth factor B knockout (Vegf-b-/-) mice showed impaired nerve repair with concomitant impaired trophic function. PMID: 25404333
11. Data indicate that VEGF-B is a high-affinity VEGFR-1 ligand that, unlike PlGF, cannot efficiently induce signaling downstream of VEGFR-1. PMID: 23821770
12. results demonstrate that the vascular endothelium can function as an efficient barrier to excess muscle lipid uptake even under conditions of severe obesity and type 2 diabetes, and that this barrier can be maintained by inhibition of VEGF-B signalling PMID: 23023133
13. the RTEF-1-driven increase of VEGF-B plays an important role in communication between the endothelium and myocardium PMID: 21169295
14. Study indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1. PMID: 21248239
15. Data show that no differences in vascular density, perfusion or immune cell infiltration upon altered Vegfb gene dosage were noted. PMID: 21124841
16. VEGF-B appears to be a coronary growth factor in rats but not in mice. PMID: 20937974
17. VEGF-B is involved in the retinal recovery processes and plays a potent role of neuroprotection in retinal ganglion cells after the optic nerve crush. PMID: 19484929
18. VEGF-B specifically controlled endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins PMID: 20228789
19. Assignment of the mouse Vegfb gene to mouse chromosome 19 B PMID: 12063409
20. when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability. PMID: 12547729
21. VEGF-B, in part through its receptor VEGF-R1, promotes angiogenesis in association with an activation of Akt and eNOS-related pathways PMID: 12805240
22. The reduction in inflammation-associated synovial angiogenesis in Vegfb(-/-) mice implicates VEGF-B in pathologic vascular remodeling in inflammatory arthritis. PMID: 13130487
23. endogenous VegfB may act to protect the brain from ischemic injury PMID: 15529014
24. a direct effect of VEGF-B isoforms in potentiating angiogenesis. PMID: 16109918
25. These results suggest a role for VEGFB in the regulation of adult neurogenesis, which could have therapeutic implications for diseases associated with central neuronal loss PMID: 16337622
26. the role of endogenous antiangiogenic VEGF isoforms in normal physiology--their down-regulation is required for effective milk production PMID: 18032632
27. VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. PMID: 18511699
28. The 60 kDa VEGF-B(186) isoform is a neuroprotective factor that protects primary motor neurons against degeneration. PMID: 18923022
29. function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases PMID: 19369214

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KEGG: mmu:22340

STRING: 10090.ENSMUSP00000025914

UniGene: Mm.15607