Mouse Xanthine Oxidase(XO) ELISA Kit

1. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9). PMID: 30336599
2. Our results demonstrated that Ripk3 was strongly upregulated in murine hearts subjected to IR injury and cardiomyocytes treated with LPS and H2O2..the present study helps to elucidate how necroptosis is mediated by ER stress, via the calcium overload /XO/ROS/mPTP opening axis PMID: 29502045
3. eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. This interplay between XOR and eNOS is proposed to play a significant role in NO homeostasis and blood pressure regulation. PMID: 27609225
4. Collectively, these results demonstrate that XO inhibition protects against WD-induced vascular oxidative stress, fibrosis, impaired vasorelaxation, and aortic stiffness in females. Furthermore, excessive oxidative stress resulting from XO activation appears to play a key role in mediating vascular dysfunction induced by chronic exposure to WD consumption in females. PMID: 28539355
5. NLRP3 inflammasome is decreased and IL-1beta secretion is inhibited in macrophages by hydroxysafflor yellow A and xanthine oxidase PMID: 27433030
6. Extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos inhibit xanthine oxidase activity and prevent hyperuricemia. PMID: 27696407
7. Our results suggest that a possible relationship between xanthine oxidase-related reactive oxygen species and TRPV1 may exist during the events preceding eccentric exercise PMID: 26987748
8. inflammasome activation accompanied by an increase in xanthine oxidoreductase activity contributed to fat pad inflammation followed by osteoarthritis progression PMID: 26903297
9. XOR is abundant in wounds and participates in normal wound healing through effects on ROS production. PMID: 25879627
10. XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species. PMID: 25800347
11. Xanthine oxidase inhibitors are potentially potent therapies for patients with NASH, particularly that associated with hyperuricemia. PMID: 25999428
12. these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis PMID: 25044064
13. The expression and the activity of XO were increased dramatically within the central nervous system of experimental autoimmune encephalomyelitis mice as compared to naive mice. PMID: 23951137
14. Reduction in XOR gene expression in mice augments lipid accumulation in adipocytes, accompanied by an increase in oxidative stress, and induces obesity with insulin resistance in older age. PMID: 24158515
15. Rat Xdh is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase. PMID: 15878860
16. Mouse Xdh is a moonlighting protein that has two distinct catalytic activities and acts a structural protein in milk fat droplets. PMID: 12502743
17. In conclusion, CS increases XOR expression, and the enzyme is both sufficient and necessary for p53 induction and CS-induced EC apoptosis. PMID: 23380026
18. we have established a mouse model for autosomal recessive early-onset renal failure due to a nonsense mutation in Xdh that is a model for xanthinuria in man. PMID: 23024809
19. These findings provide new insight into XOR functions and demonstrate the power of untargeted metabolite profiling for systemic discovery of direct and indirect consequences of gene mutations and drug treatments. PMID: 22723833
20. Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. PMID: 22095983
21. Age-related changes in xanthine oxidase activity and lipid peroxidation, as well as in the correlation between both parameters, in plasma and several organs from female mice PMID: 21626205
22. These results show that XOR is an important functional component of differentiation whose diminished expression contributes to breast cancer aggressiveness PMID: 21775420
23. The xanthine oxidoreductase expression in tissues is enhanced in germ free mice and this may explain the apparently greater tissue nitrate reductase activity observed in these animals. PMID: 20142047
24. Xanthine oxidase (XO) activity contributes to the increased superoxide anion detected within the extracellular space of skeletal muscles during nondamaging contractile activity. PMID: 19828843
25. the expression and membrane association of XOR in the mammary gland are tightly regulated by secretory activity, and the apical membrane association of XOR regulates the coupling of lipid to the plasma membrane during milk lipid secretion PMID: 12456835
26. Deficiency of NOS1 leads to profound increases in XOR-mediated O(2)(.-) production, which in turn depresses myocardial excitation-contraction coupling. PMID: 15486091
27. XOR activity is an endogenous physiological regulator of COX-2 expression. PMID: 15528468
28. Stress activation of mammary epithelial cell Xdh is mediated by p38 MAPK and CCAAT-enhancer-binding protein-beta. PMID: 16452486
29. We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI. PMID: 16632522
30. XOR is a novel regulator of adipogenesis and of PPARgamma activity and essential for the regulation of fat accretion. PMID: 17276354
31. Although, numerous free radical generating systems may contribute to the postanoxic microglial cell damage, the xanthine-oxidase-mediated oxidant production seems to be of major importance. PMID: 17364940
32. Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury. PMID: 18669934
33. XOR derived ROS mediated the migratory effect and also modulated COX-2 and MMP levels and function. PMID: 18767115
34. Nox2-containing NADPH oxidase and xanthine oxidase are sources of superoxide in mouse trachea. PMID: 19076165
35. PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase PMID: 19531472
36. XOR gene disruption induced the depletion of uric acid and the accumulation of triglyceride-rich substances, xanthine, and hypoxanthine in the renal tubules. PMID: 19667249

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KEGG: mmu:22436

STRING: 10090.ENSMUSP00000024866

UniGene: Mm.11223