Function
(From Uniprot)
The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.
Gene References into Functions
- findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE. PMID: 29111742
- golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety. PMID: 26497031
- The Mbp(+/-) mice exhibited defects of sensorimotor gating, as evidenced by reduced prepulse-inhibition, and a late-onset catatonia phenotype. PMID: 27470661
- myelin basic protein (MBP) is inhibitory to both primitive neural stem cells and definitive neural stem cells derived colony formation. PMID: 27573615
- CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP). PMID: 28076777
- to further characterize the mechanism regulating mbp transcription, study defined M3 structure/function relationships; multiple M3 regulatory element combinations were found to drive expression in oligodendrocytes and Schwann cells with a minimal 129 bp sequence conferring expression in oligodendrocytes throughout myelin elaboration, maintenance and repair PMID: 26507463
- Results show the expression of sncRNA715 in Schwann cells and its inverse correlation with Mbp mRNA in cultured cells and the sciatic nerve. Its inhibitory effect on MBP was confirmed in differentiating primary Schwann cells. PMID: 26317513
- Results suggest that GAL is a regulator of myelination, as demonstrated by MBP synthesis, and may be one of the myelination promoters PMID: 25450959
- Data indicate that 18.5 kDa myelin basic protein (MBP) segment upstream of the primary SH3-ligand is involved in interaction. PMID: 25343306
- Data suggest that prenatal alterations in expression of various fetal brain proteins (including up-regulation of Mbp) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior. PMID: 25849768
- Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities. PMID: 24713852
- Data indicate a role for myelin basic protein (MBP) isoforms in protein-protein interactions during membrane and cytoskeletal extension and remodeling in oligodendrocytes (OLGs). PMID: 24956930
- Disappearance of 21.5 pMBP corresponded to demyelination and its reappearance corresponded to prevention of demyelination. PMID: 24459152
- Golli-BG21 enhanced SCP1/GIP phosphatase activity, whereas PKCalpha-phosphorylated BG21 inhibited its activity, suggesting a potential role of BG21 as a molecular switch ("quick-brake mechanism") on SCP1/GIP. PMID: 24751520
- MBP expression in cultured Fmr1 KO oligodendrocytes is similar to wild type, and expression of MBP in brain homogenates of the Fmr1 KO mouse to be similar to wild type. PMID: 23891804
- myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate. PMID: 23762018
- Myelin basic protein-21.5 kDa in the nucleus promotes oligodendrocyte proliferation, while melin basic protein-18.5-kDa in plasma membrane does not. PMID: 23184356
- 21.5-kDa MBP contains two non-traditional PY-nuclear-localization signals, and arginine and lysine residues within these motifs were involved in subcellular trafficking of this protein to the nucleus, where it may have functional roles during myelinogenesis. PMID: 22609403
- Loss of MBP is associated with aging and hearing loss. PMID: 22496821
- Myelin basic protein (MBP) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath. PMID: 21824506
- Regulation of the Mbp gene, along with the relative amount of expressed Mbp protein, suggests that the immortalized cell lines containing them are representative of immature oligodendrocytes. PMID: 21472765
- The results of this study suggested that MBP's SH3 ligand domain plays a key role in intracellular protein interactions in vivo and may be required for proper membrane elaboration of developing oligodendrocytes. PMID: 21887699
- Molecular dynamics simulations were conducted to investigate the conformation of the immunodominant epitope of acetylated myelin basic protein residues 1-11 and its altered peptide ligands, mutated at position 4 to an alanine or a tyrosine residue. PMID: 22042377
- define hnRNP F as a regulatory element of MBP expression in oligodendrocytes and imply an important function of hnRNP F in the control of myelin synthesis. PMID: 22128153
- there is an N-terminal binding domain in MBP for Ca(2+)-CaM PMID: 21889463
- Human umbilical cord blood-derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice. PMID: 20925478
- our data indicate a key role for golli proteins in the regulation of TRPC-mediated Ca(2+) influx PMID: 21389218
- The density of high-voltage-activated currents is reduced in oligodendroglial precursor cells recorded in golli-deficient tissue, while low-voltage-activated currents remain unaltered in these cells. PMID: 20607717
- The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells. PMID: 20862255
- These results are the first to provide atomic-level detail of a membrane-anchoring segment of MBP. PMID: 20713009
- Secondary structure and solvent accessibility of a calmodulin-binding C-terminal segment of membrane-associated myelin basic protein. PMID: 20831157
- When MBP was reconstituted with myelin-mimetic membranes, there was a rearrangement of secondary structure components upon addition of zinc. PMID: 20169373
- results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins PMID: 19855925
- the divalent cations copper and zinc induce a compaction of the extended myelin basic protein in vitro, suggestive of a tertiary conformation that may reflect its arrangement in myelin. PMID: 19903451
- helical tubular vesicles were formed by binary monolayers containing a nickel-chelating lipid and phosphoinositides in the presence of myelin basic protein PMID: 11841829
- Myelin basic protein has a role in contact-mediated expression of inducible Nitric Oxide Synthase in microglial cells PMID: 12176974
- calmodulin-binding properties of N- and C-terminal deletion mutants of MBP PMID: 12901870
- MBP has an alpha-helix tilted 9 degrees, and the central lysine is positioned for side-chain interaction with the negatively charged phospholipid head groups PMID: 14630913
- role in expression of insulin-like growth factor 1 PMID: 15139287
- electron paramagnetic resonance of MBP-CaM interactions PMID: 15522783
- An enhancer 9.0 kb upstream of Mbp (MbpSCE1) activates Mpz specifically in Schwann cells in transgenic mice. MbpSCE1 is active in both Schwann cells and oligodendrocytes, but by diverse mechanisms. PMID: 15525335
- Fyn plays critical roles in promoting accelerated MBP expression during myelinogenesis in a MBP isoform-preferential manner, and QKI may act in the same pathway downstream of Fyn for MBP mRNA homeostasis PMID: 15528192
- Taken together, these results demonstrate that microglia and/or microglia secreted factors, are necessary for the LPS-promoted proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process. PMID: 15546149
- Deimination of MBP, a posttranslational modification which occurs early in life, attenuates the ability of MBP to polymerize and bundle actin, and to bind it to a negatively charged membrane. PMID: 15736962
- microglial activation of C/EBPbeta but not NF-kappaB by T cell:microglial contact is a gender-specific event, resulting in the inability of male MBP-primed T cells to induce microglial expression of proinflammatory molecules PMID: 16046404
- role for golli proteins in oligodendrocyte differentiation, migration, and/or myelin elaboration in the brain PMID: 16049176
- Transient transfections with a luciferase reporter gene driven by the myelin basic protein promoter define how changes in the molecular composition of these transcriptional complexes modulate myelin gene expression. PMID: 16148239
- discovered epitope-specific antibody-mediated degradation of MBP suggests a mechanistic explanation of the slow development of neurodegeneration associated with multiple sclerosis PMID: 16387849
- These results demonstrate that both STOP and MBP function as microtubule-stabilizing proteins in differentiating oligodendrocytes and could be important for the PMID: 16773649
- Golli-deficient T cells were hyperproliferative and showed enhanced calcium entry upon T cell receptor stimulation. PMID: 16782028
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Involvement in disease
Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp.
Subcellular Location
[Isoform 13]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 12]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 11]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 10]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 9]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 8]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 7]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 6]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 5]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 4]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; [Isoform 3]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 1]: Cytoplasm. Nucleus.
Protein Families
Myelin basic protein family
Tissue Specificity
In the embryo, isoform 1-isoform 3 are found in neurons within the central nervous system (primarily in pioneer neurons important in the formation of the cortex) and the peripheral nervous system. They are also expressed in the thymus, gut, lung and kidne
