| Gene References into Functions |
- Results show decreased SRF levels in the substantia nigra (SN) of rotenone-treated rats that was associated with the loss of tyrosine hydroxylase (TH)-positive neurons. SRF expression was also reduced in rotenone-treated PC12 cells in vitro. In addition, Srf knockdown augmented rotenone-induced toxicity in PC12 cells. In contrast, overexpression of Srf attenuated the cells' sensitivity to rotenone. PMID: 29196028
- Expression of Beclin-1 and LAMP-2 in Rat Hippocampus under Conditions of Simulated Gravity Overload in the Caudocranial Vector PMID: 29797121
- Data suggested that Beclin-1-mediated autophagy impairs the expression and function of cleaved caspase-8 to protect against cadmium-induced activation of apoptosis through Fas/FasL signaling pathway. PMID: 28428545
- that after Caspase 3-mediated Beclin 1 cleavage at 146/149 sites, the N-terminal fragments of Beclin 1 may partially translocate into nuclei in neurons subjected to AD-like injury PMID: 28964771
- Lutein-induced autophagy was mediated by the upregulation of BECN1 in IEC-6 cells. PMID: 28893091
- treatment with an autophagy inhibitor decreased LC3II expression.However, miR-30b overexpression decreased Pi-induced expression of autophagy-related marker genes such as BECN1, ATG5, and LC3b, whereas miR-30b downregulation increased Pi-induced expression of these genes. In addition, we found that miR-30b PMID: 28578340
- These results suggest that EA protects against ischemic stroke through the inhibition of autophagosome formation and autophagy, which is mediated through the mTORC1-ULK complex-Beclin1 pathway PMID: 26647915
- in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death. PMID: 26386349
- Hypoxia-affected fetal renal development was associated with renal apoptosis and Beclin 1 signaling-mediated autophagy. PMID: 24872334
- Beclin 1 has an essential role as a regulator between autophagy and apoptosis in the setting of neointimal formation PMID: 25238224
- veal a novel function of GA binding protein in the regulation of autophagy via transcriptional activation of the BECN1-PIK3C3 complex PMID: 25046113
- These results suggest that IPC inhibits Beclin 1-dependent excessive autophagy in reperfusion phase and cooperates with anti-apoptosis pathway to diminish the cell death induced by the myocardial I/R injury. PMID: 23392707
- Significantly higher level of Beclin-1 and LC3B-II/LC3B-I ratio (both definitive autophagy biomarkers) was observed in the fibrillated myocardium, versus tissue from the nonfibrillated hearts PMID: 23590156
- Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling. PMID: 24324270
- Level of beclin-1 in acute on chronic liver failure was lower than control. PMID: 24579466
- The results of yhis study found that levels of autophagy markers such as LC3 and Beclin 1 are elevated in the GABAergic interneurons of the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain. PMID: 23665054
- Beclin-1 upregulation results in enhanced levels of autophagy. PMID: 22917477
- beta-asarone can increase Bcl-2 level, finally interfere with the functions of Beclin 1 during the execution of autophagy. PMID: 22306244
- Inhibition of autophagy by Beclin 1 knockdown can attenuate the secondary thalamic damage after focal cerebral infarction. PMID: 22108007
- beclin1 may be involved in the pathogenesis of diabetic nephropathy with the mechanism related to the process of programmed cell death. PMID: 21866636
- Beclin 1-independent autophagy is an important contributor to both the caspase-dependent and -independent components of neuronal apoptosis and may be considered as an important therapeutic target in neural conditions involving apoptosis PMID: 21646862
- Data reveal that Beclin 1 and ATG5 play key roles in morphine-induced autophagy, which may contribute to morphine-induced neuronal injury. PMID: 20190558
- Hypoxia triggers a feedback mechanism that delays apoptosis of oxygen-deprived malignant intestinal epithelial cells and is driven by hypoxia-induced Beclin 1 downregulation. PMID: 19901551
- The inhibition of autophagy by urocortin is mediated in part by inhibition of Beclin1 expression, an effect which is mediated by activation of the PI3 kinase/Akt pathway but which does not involve activation of p42/p44 MAPK. PMID: 16697404
- Beclin 1 protein began to elevate at 1 h time point post-TBI in neurons, 3 d later in astrocytes, and peaked at about 8 d post-TBI. PMID: 18500386
- stimulation of autophagy by -methyl D-aspartate 2B glutamate signaling may be regulated by redistribution of Beclin-1 in membrane rafts PMID: 19335206
- the AMPK-MEK/ERK-TSC-mTOR pathway regulation of Beclin 1 represents different thresholds responsible for a protective or destructive autophagy PMID: 19520853
- Data show that RNA interference-mediated downregulation of Beclin1 improves outcomes after transient middle cerebral artery occlusion. PMID: 19574998
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| Subcellular Location |
Cytoplasm, Golgi apparatus, trans-Golgi network membrane, Peripheral membrane protein, Endosome membrane, Peripheral membrane protein, Endoplasmic reticulum membrane, Peripheral membrane protein, Mitochondrion membrane, Peripheral membrane protein, Cytoplasmic vesicle, autophagosome |
