Rat Fibronectin type III domain-containing protein 5(FNDC5) ELISA kit

1. The results of the study suggest that irisin values increase in thyroid dysfunction, hypo- and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal. PMID: 29182513
2. e suggested that levels of circulating irisin are the result of the sum of the irisin produced by different depots of adipose tissue and skeletal muscle. This study shows for the first time that there are differences in FNDC5 expression depending on white adipose tissue depots. PMID: 27432282
3. The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin biosynthesis and glucose-stimulated insulin secretion, and beta-cell apoptosis are reported. PMID: 28724742
4. results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke. PMID: 28961497
5. Irisin could affects the nutrition behavior and energy metabolism. PMID: 28242329
6. Study demonstrated that irisin promotes beta cell proliferation through the ERK and p38 MAPK signaling pathways. Irisin can also inhibit the high-glucose-induced apoptosis of INS-1 cells and improve the function of pancreatic beta cells. Findings suggest that irisin may have applications in the prevention and treatment of type 2 diabetes mellitus because of its protective effect on the secretion of pancreatic beta cells. PMID: 28394923
7. Swimming exercise increases serum Fndc5 level. PMID: 27177924
8. the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis. PMID: 26961074
9. the irisin affects the expression of the UCPs in a central way. PMID: 26926562
10. Methylprednisolone and carnosine and the combination of the two, significantly increased irisin in plasma and were accompanied by a significant rise in irisin immunoreactivity of brain and spinal cord tissues of the injured rats PMID: 26142757
11. studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities. PMID: 25820670
12. the fat-burning protein irisin locally produced in peripheral and central tissues could act as a gatekeeper of metabolic energy regulation in those tissues PMID: 25261800
13. changes in irisin mRNA and protein levels in rat muscle after acute exercise are limited and depend on training status and the muscle type; irisin serum levels remained stable after acute exercise or endurance training PMID: 24930518
14. Irisin increases near myocardial connective tissue, with production in skeletal muscle, liver and kidney after myocardial infarction. PMID: 24576483
15. High supernatant irisin could come from connective tissues around skeletal muscle, especially nerve sheaths located within it. Skeletal muscle is probably not a main irisin source. PMID: 24345335
16. This immunohistochemical results demonstrate the expression of irisin immunoreactivity in three types of cells: skeletal, cardiac muscle, and Purkinje cells of the cerebellum. PMID: 23470775
17. Further research is needed to examine whether other adipose tissue-derived factors up-regulate FNDC5 transcription and/or inhibit irisin biosynthesis from FNDC5 PMID: 23498898
18. In addition to skeletal muscles, white adipose tissue also secretes FNDC5; hence, it may behave as an adipokine as well as a myokine. PMID: 23593248

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KEGG: rno:260327

STRING: 10116.ENSRNOP00000048830

UniGene: Rn.18757