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| Code | CSB-E08587r |
| See More Details |  |
| Product Type | ELISA Kit |
| Size | 96T,5×96T,10×96T |
| Uniprot No. | P06866 |
| Lead Time | 3-5 working days |
| Abbreviation | HP |
| Target Name | haptoglobin |
| Alias | BP, HP2-ALPHA-2, HPA1S, MGC111141, binding peptide|haptoglobin alpha(1S)-beta|haptoglobin alpha(2FS)-beta|haptoglobin, alpha polypeptide|haptoglobin, beta polypeptide |
| Species | Rattus norvegicus (Rat) |
| Sample Types | serum, plasma, cell culture supernates, tissue homogenates,bronchoalveolar lavage fluid, urine |
| Detection Range | 0.156 μg/mL-10 μg/mL |
| Sensitivity | 0.039 μg/mL |
| Assay Time | 1-5h |
| Sample Volume | 50-100ul |
| Detection Wavelength | 450 nm |
| Research Area | Cardiovascular |
| Protocol |
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
|
| Assay Principle | quantitative |
| Measurement | Sandwich |
| Target Details | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn s disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson s disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. |
| HGNC | 16937 |
| RGD | 708572 |
| MGI | 1929501 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity). |
| Subcellular Location | Secreted |
| Protein Families | Peptidase S1 family |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Database Links |
KEGG: rno:24464 UniGene: Rn.10950 |
Hp Antibodies for Rat
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA17069A0Rb | Hp Antibody | Rat | ELISA, WB, IHC |
| CSB-PA17069C0Rb | Hp Antibody, FITC conjugated | Rat | ELISA |
| CSB-PA17069B0Rb | Hp Antibody, HRP conjugated | Rat | ELISA |
| CSB-PA17069D0Rb | Hp Antibody, Biotin conjugated | Rat | ELISA |
Hp Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP010691RA CSB-EP010691RA CSB-BP010691RA CSB-MP010691RA |
Recombinant Rat Haptoglobin(Hp) | Yeast E.coli Baculovirus Mammalian cell |
| CSB-RP170694r | Recombinant Rat Haptoglobin(Hp),partial | E.coli |
Mouse Arachidonic Acid(AA) ELISA Kit
Detect Range: 15.625 ng/mL-1000 ng/mL
Sensitivity: 13.797 ng/mL
Mouse Angiotensin converting enzyme,ACE ELISA Kit
Detect Range: 1.56 ng/mL-100 ng/mL
Sensitivity: 0.39 ng/mL
Human apolipoprotein E (Apo-E) ELISA Kit
Detect Range: 15.62 ng/mL-1000 ng/mL
Sensitivity: 3.9 ng/mL
