Name: Rat Haptoglobin,Hpt/HP ELISA KIT
Brand: CUSABIO
SKU: CSB-E08587r

Product Details

Target Name	haptoglobin
Alternative Names	Hp ELISA Kit; Ba1-647 ELISA Kit; Haptoglobin ELISA Kit; Liver regeneration-related protein LRRG173) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain] ELISA Kit
Abbreviation	HP
Uniprot No.	P06866
Species	Rattus norvegicus (Rat)
Sample Types	serum, plasma, cell culture supernates, tissue homogenates,bronchoalveolar lavage fluid, urine
Detection Range	0.156 μg/mL-10 μg/mL
Sensitivity	0.039 μg/mL
Assay Time	1-5h
Sample Volume	50-100ul
Detection Wavelength	450 nm
Research Area	Cardiovascular
Assay Principle	quantitative
Measurement	Sandwich
Troubleshooting and FAQs	ELISA kit FAQs
Storage	Store at 2-8°C. Please refer to protocol.
Lead Time	3-5 working days

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Target Background

Function (From Uniprot)	As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway (By similarity).
Gene References into Functions	This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction. PMID: 23172820 Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats PMID: 22254015 activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator. PMID: 20155810 Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury. PMID: 20016097 Hp-mediated haemoglobin catabolism in lung cells may be an efficient mechanism to reduce oxidative damage associated with haemolysis PMID: 11865979 Haptoglobin gene expression regulation PMID: 11865981 Hp is transcriptionally modulated throughout prenatal hepatic development by fetal p53 protein. PMID: 11991649 upregulated in reactive astrocytes after transient forebrain ischemia in rats PMID: 12368655 Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the acute-phase response regulation during the later phase of differentiation and in the adult. PMID: 16172914 Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals. PMID: 17616219 that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells. PMID: 17910034 lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription. PMID: 19521970 Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response. PMID: 19545490 Show More Hide All
Subcellular Location	Secreted
Protein Families	Peptidase S1 family
Tissue Specificity	Expressed by the liver and secreted in plasma.
Database Links	KEGG: rno:24464 UniGene: Rn.10950

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Check Code：

Code	CSB-E08587r
Size	96T,5×96T,10×96T
Trial Size
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Rat Haptoglobin,Hpt/HP ELISA KIT

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