Rat Interleukin 10,IL-10 ELISA KIT

Instructions
Code CSB-E04595r
Size 96T,5×96T,10×96T
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Product Details

Target Name interleukin 10
Alternative Names Il10 ELISA Kit; Il-10Interleukin-10 ELISA Kit; IL-10 ELISA Kit; Cytokine synthesis inhibitory factor ELISA Kit; CSIF ELISA Kit
Abbreviation IL10
Uniprot No. P29456
Species Rattus norvegicus (Rat)
Sample Types serum, plasma, cell culture supernates, tissue homogenates
Detection Range 3.12 pg/mL-200 pg/mL
Sensitivity 0.78 pg/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
 SampleSerum(n=4)
1:1Average %92
Range %88-98
1:2Average %96
Range %91-101
1:4Average %90
Range %85-95
1:8Average %93
Range %90-96
Recovery
The recovery of rat IL-10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
Sample TypeAverage % RecoveryRange
Serum (n=5) 9287-98
EDTA plasma (n=4)9590-102
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
pg/mlOD1OD2AverageCorrected
2002.611 2.671 2.641 2.474
1001.873 1.867 1.870 1.703
501.206 1.234 1.220 1.053
250.804 0.817 0.811 0.644
12.50.515 0.527 0.521 0.354
6.250.387 0.399 0.393 0.226
3.120.314 0.327 0.321 0.154
00.155 0.179 0.167  
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Citations

Q&A and Customer Reviews

 Customer Reviews
  • Sample type: Culture supernatants
    Sample species: Rat
    Review: The levels of cytokines in the different groups (n = 9). The production of IL-10 in supernatant of cultured PMNs was detected by ELISA. PMNs were cultured with NPS-2143 (100 nM), cinacalcet (100 nM), and PDTC (100 nM) for 12 h after stimulated by fMLP (10 nM) for 2 min. #P < 0 05 versus control group, ∗P < 0 05 versus fMLP group, and △P < 0 01 versus fMLP + CIN group.
    PMID: 29081886
  • Sample type: Culture supernatants
    Sample species: Rat
    Review: HO‐1 overexpression increases the production of paracrine factors from MSCs under PC stimulation. PCs were applied to all types of stem cells for 7 days, and then the levels of IL-10 (g) in culture supernatants were analyzed by enzyme-linked immunosorbent assays. All data are expressed as mean ± SEM (n = 6). *p < 0.05 versus MSC + PBS and MSC‐HO‐1 + PBS groups, #p < 0.05 versus MSC + PC group, and Δp < 0.05 versus MSC-HO-1 + PC group.
    PMID: 30362554
  • Sample type: Colorectal tissues
    Sample species: Rat
    Review: The anti-inflammatory cytokines IL-10 is decreased to a low level after TNBS exposure, whereas treatment with middle- or high-dose of BD-SNEDDS, BD-suspension, or AZA notably restored these anti-inflammatory cytokines. Data are expressed as mean±SD and analyzed by ANOVA followed by Dunnett’s test. ##P,0.01 vs intact group, **P,0.01 and *P,0.05 vs the vehicle group, P,0.05 and P,0.01 vs BD-suspension group.
    PMID: 30319255
  • Sample type: Tissues
    Sample species: Rat
    Review: IL-10 levels were obtained in treated and untreated groups (a) and comparison to the highest level obtained for each cytokine in periodontitis group (positive control).
    PMID: 30194012
  • Sample type: Culture supernatants
    Sample species: Rat
    Review: Compared with the vector-NC group, decreased  IL-10 level were found in the P2X7-vector group (p < 0.05).
    PMID: 30892077
  • Sample type: Plamsa
    Sample species: Rat
    Review: Effect of KJL on IL-1 in plasma. Data are presented as the mean ± SD. ##P < 0.01, #P < 0.05 versus the control group; **P < 0.01, *P < 0.05 versus the TNBS group. (n = 8–12).
    PMID: 28750820
  • Sample type: Liver homogenate tissue
    Sample species: Rat
    Review: Effect of PTX on BDL-induced changes in liver IL-10, fourteen days post-operation, paclitaxel (PTX) (0.3 mg/kg/ip) was administered three times a week for 2 weeks. Hepatic IL-10 level were measured thereafter. Data are expressed as mean ± SD (n=6).
    PMID: 30243650
  • Sample type: Culture supernatants
    Sample species: Rat
    Review: Nrf2 knockdown reversed the anti-inflammatory effects of SalC. Nrf2 siRNA reversed SalC-induced IL‑10 downregulation. All data are presented as mean ± SD of four independent experiments. ##P < 0.01 vs control group, ⁎⁎P < 0.01 vs LPS group, scale bar = 20 μm.
    PMID: 30142530
  • Sample type: Jejunal mucosa tissues
    Sample species: Rat
    Review: Effect of ethanolamine on cytokines of weaned rats. The concentrations of cytokines in the jejunal mucosa were not different among groups.
    PMID: 29789027
  • Sample type: Brain tissues
    Sample species: Rat
    Review: Concentrations of the IL10 and their receptors were significantly lower in the serum than in the central nervous system in both SH and WKY rats (p < 0.001).
    PMID: 30539780

Target Data

Function Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Gene References into Functions
  1. Low IL10 expression is associated with liver fibrosis. PMID: 30243650
  2. A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti-secretary, mucoprotective and IL-10 mediated anti-inflammatory mechanisms. PMID: 29924982
  3. IL10 suppressed inflammation, facilitated retinal pigment epithelium cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression in rhegmatogenous retinal detachment. PMID: 29568872
  4. ghrelin with high doses (80 and 160 mug/kg) significantly reduced pain intensity in both the early and the late phases of pain. The serum levels of cytokines, IL-10, and TGF-beta1 showed a significant elevation with ghrelin at the dose of 160 mug/kg. PMID: 27703278
  5. IL-10 not only attenuates neuronal apoptosis, but also promotes neurite outgrowth and synapse formation via the JAK1/STAT3 signaling pathway. PMID: 27456198
  6. both the AV and the LV vector systems were able to transfect limbal graft tissue ex vivo with biologically active IL-10, leading to delayed rejection compared to the controls. PMID: 28925732
  7. Addition of 320 (48) and 640 (96) mg/L (mg/kg BW) boron markedly reduced the serum IgG concentrations; splenic IL-2 and IL-10 expression; the number of CD3(+), CD4(+) and PCNA(+) cells; and increased the number of splenic CD8(+) and caspase-3(+) cells and promoted caspase-3 expression in CD3(+) cells. PMID: 28092075
  8. The expression levels of IL-10, NF-kappaB and MMP-3 in the intervertebral disc tissue samples were higher in test animals than in controls at one-month, three-months and six-months after surgically induced cervical spondylosis. Cervical degeneration may be accompanied by changes in IL-10. PMID: 29197741
  9. Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti-Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta-Carotene, and Spirulina fusiformis: Role of NF-kappaB, iNOS, IL-6, and IL-10.( PMID: 28387444
  10. the effects of dapagliflozin on STAT3 activity and myocardial IL-10 levels can be reversed by 3-morpholinosydnonimine, a peroxynitrite generator. Taken together, these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling PMID: 28132924
  11. TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. PMID: 28258441
  12. this study shows that transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft PMID: 27317647
  13. this study shows that that N-Acetyl-l-cysteine acts as an antipyretic via IL-10 stimulation PMID: 27363620
  14. Transplantation of mesenchymal stem cells overexpressing IL10 preserves myocardial viability and left ventricular rfunction in rats with myocardial infarction. PMID: 28322445
  15. The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge PMID: 28686630
  16. use of rebamipide retards CCl4-induced hepatic fibrosis, which is associated with significant increases in liver levels of IL-10 PMID: 26849241
  17. Data suggest that vitamin A, when used as an unnecessary dietary supplement, decreases skeletal muscle expression of anti-inflammatory mediators interleukin-10 and heat shock protein 70, important factors for positive exercise adaptations and tissue damage prevention. PMID: 28368329
  18. Exercise combined with ultrasound attenuates neuropathic pain in rats and is associated with downregulation of IL-6 and TNF-alpha, and with upregulation of IL-10. PMID: 28319508
  19. Results uncover a novel neuroimmune modulation of GABAergic neurotransmission as well as a novel role for IL-10 in response to acute ethanol intake. Early increase in IL-10 levels may contribute to the complex changes in neuroimmune signaling that occur after acute exposure to ethanol. Further, IL-10 has an inhibitory effect on GABAergic transmission, possibly leading to inhibition of sleep PMID: 27016017
  20. Nonsteroidal Anti-Inflammatory Drugs data provide opportunities to investigate such associations and specifically imply that potential interrelationships among OTC NSAID use, IL-10 genotype, and IL-10 cytokine levels deserve further study PMID: 28135825
  21. The expression of IL-10 and TGF-beta in the CD25 siRNA group increased, while IFN-gamma, IL-1beta, and TNF-alpha expression decreased, as well as no significant changes in Foxp3 expression were observed at day 14 post-operation. PMID: 27567557
  22. IL10 has a role in preventing -induced cell death in rat hippocampal cultures PMID: 28063948
  23. IL-10 592 polymorphism was associated with diabetic retinopathy susceptibility, suggesting that the gene polymorphism might be a risk factor for diabetic retinopathy PMID: 26492380
  24. Mesenchymal stromal cells inhibit Human antigen R (HuR) trascription, an enhancer of RENmRNA stability by IL10 release PMID: 26866372
  25. Mesenchymal stem cells decrease apoptosis and improve learning-memory function in hypoxic-ischemic brain damage rats by suppressing the TLR2/NFkappaB signaling pathway via a feedback mechanism that reduces IL-10 release. PMID: 26475712
  26. Green tea intake reduces expression of the pro-inflammatory cytokine TNF-alpha and the osteoclastogenic mediator RANKL to normal levels while increasing expression of the anti-inflammatory cytokine IL-10. PMID: 26270535
  27. IL-10 released from activated glial cells in the VLO can potentially attenuate allodynia while IL-1beta released from activated glial cells in the VLO can potentially maintain or facilitate allodynia PMID: 25617163
  28. The objectives of these studies were to investigate the responses of IL-10 receptors (IL-10Rs) and IL-10 signalling proteins (IL-10SPs) in hyperoxic foetal alveolar type II cells. PMID: 26059905
  29. Leydig cell-conditioned media dose-dependently stimulated expression of transcription factor Foxp3 and secretion of IL-10 in splenic CD4+ T cells, an effect abolished by addition of the anti-androgen flutamide. PMID: 25598450
  30. Exercise increased the amount of IL-1beta and IL-10 positive chondrocytes PMID: 25702530
  31. Study shows that, in addition to inducing persistent memory deficits, maternal deprivation increased the levels of the anti-inflammatory cytokine, IL-10, and of the pro-inflammatory cytokine, TNF-alpha, and decreased the levels of BDNF in the adulthood PMID: 25182413
  32. atropine in malathion intoxicated rats had no effect on suppression of the synthesis of proinflammatory cytokines TNF, IL-1g and IL-6 as well as the content of anti-inflammatory cytokines IL-10 and IL-13. PMID: 26591203
  33. Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-alpha. PMID: 25096025
  34. the preserved ability of macrophages from aged AO rats to synthesize not only proinflammatory TNF-alpha, but also immunoregulatory IL-10 cytokine most likely contributes to their longer average life compared with DA rats PMID: 25009084
  35. The dysfunction of dendritic cells and the increase of IL-10-producing Breg and Foxp3(+) Treg might play important roles in hepatocellular carcinoma progression PMID: 25066760
  36. SOCS-3 was involved in cerebral vasospasm after subarachnoid hemorrhage via an IL-6- and IL-10-related mechanism. IL-10 levels increased during the first 6 h after SAH, after which this increase tapered off. PMID: 24463741
  37. results suggest that IL-10/HMOX1 signaling is involved in modulation of cochlear inflammation through inhibition of MCP-1/CCL2 regulation in SLFs PMID: 25780042
  38. The neuronal apoptosis rate was positively correlated with the levels of TNF-alpha and IL-6, and negatively correlated with IL-10 and GDNF. PMID: 24706318
  39. cells from long-lived rats exhibited a dramatic increase in IL-10 mRNA expression followed by diminished TNF-alpha and IL-6 mRNA expression, and comparable expression of IL-1beta mRNA relative to adult rats. PMID: 25081109
  40. Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10. PMID: 25329858
  41. Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury PMID: 25471580
  42. We found cardiac and histological changes compatible with the inflammatory process triggered by acute pancreatitis with the promotion of local myocardial cytokine production. PMID: 24865534
  43. study provides novel evidence that IL-10 plays an up-regulatory role in the anti-hypertensive activity of CCL5 in SHR VSMCs PMID: 24656930
  44. The high expression in IL-1beta and IL-10 levels in small bowel and colon might explain the accelerated healing process in these wounds in comparison to skin and muscle tissues. PMID: 24114903
  45. Daily treatment with anti-IL10 antibody significantly increased paw edema. PMID: 23765634
  46. Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells. PMID: 24527865
  47. Gemfibrozil plus metformin decrease MMP-9, increase IL-10 and adiponectin acting. PMID: 23111552
  48. Pro-inflammatory cytokines from area postrema and organum vasculosum laminae terminalis are modulated by IL-10 antibodies. PMID: 23388469
  49. GSK-3beta modulates inflammatory IL-10 levels released from cortical glia. PMID: 22796213
  50. These data in cardiomyocytes suggest that IL-10 induced anti-apoptotic signaling involves upregulation of TLR4 through MyD88 activation. PMID: 23141143
  51. some evidence about existence of the novel mechanism underlying the rapid neuroprotective effect of anti-inflammatory cytokine IL-10 against hypoxia-induced neurological deteriorations. PMID: 23178472
  52. IL-10 blocks the angiotensin II-induced decrease in delayed rectifier K+ current, a result consistent with a direct inhibitory action of interleukin-10 on angiotensin-II induced excitation of hypothalamic neurons. PMID: 23426971
  53. MicroRNA-27a regulates cardiomyocytic apoptosis during cardioplegia-induced cardiac arrest by targeting interleukin 10-related pathways. PMID: 23143062
  54. Animals inoculated with herpes simplex virus (HSV)-based gene transfer vector vIL10) have a statistically significant reduction in level of neuropathic pain after traumatic spinal cord injury compared to injured rats. PMID: 22593113
  55. High IL-10 expression is associated with B-cell lymphoma. PMID: 23185784
  56. Glutamate significantly increases lipopolysaccharide-stimulated IL-10 release from astrocytes by 166% and significantly upregulates IL-10 mRNA levels. PMID: 22326966
  57. Changes of IL-10 protein in dorsal root ganglia (DRG) nonassociated with damaged nerve could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of DRG neurons for regenerating their axons. PMID: 21763399
  58. Glutamate substantially increases the release of anti-inflammatory cytokine IL-10 (but not IL-1beta release) activated by a high concentration of lipopolysaccharide. PMID: 21081156
  59. RhoA can aggravate the pathology changes of ALI rats, which might be related to up regulating expression of IL-8 and down regulating expression of IL-10 by RhoA. PMID: 22152812
  60. Cobalt protoporphyrin can up-regulate HO-1 expression in bone marrow-derived mesenchymal stem cells, which increases IL-10 secretion significantly. PMID: 21129280
  61. connection of NO/IL-10/PECAM-1 during in vivo inflammatory conditions elicited by LPS has been shown PMID: 21564091
  62. Osmotic pump infusion of IL-10 in rats protected against LPS-induced cell death of dopaminergic neurons suggesting that the reduction in microglia-mediated release of inflammatory mediators may contribute to the anti-inflammatory effect of IL-10. PMID: 21887889
  63. data indicate that under the influence of the testicular environment, macrophages adopt an alternatively activated phenotype, involving reduced capacity for proinflammatory gene expression, constitutive IL-10 production PMID: 21498587
  64. Increased interleukin 10 is associated with reduced cardiac function in rats following coronary microembolization. PMID: 20625799
  65. IL-6 and IL-10 are important physiological contributors to the central insulin and leptin action mediated by physical activity, linking it to hypothalamic ER stress and inflammation. PMID: 20808781
  66. The rise of the selective cardioinhibitory cytokines may be interpreted as the adaptive response of jeopardized myocardium to the cardiac dysfunction resulting from MDMA injection. PMID: 20420568
  67. Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 expression in rat brain. PMID: 20193756
  68. Evidence supports the ability of central IL-10 to attenuate peripheral lipopolysaccharide (LPS)-induced changes in food intake and energy expenditure as well as the neurochemical and inflammatory consequences of LPS. PMID: 20045008
  69. Data describe the effect of exercise in rats with heart failure after post-myocardial infarction, with regard to expression of TNF-alpha and IL-10 in the soleus and extensor digitorum longus (EDL), muscles with different fiber composition. PMID: 19948415
  70. IL-10 plays an important role in CD4(+)CD25(+) T cell inducing immune tolerance of allogeneic liver transplantation. PMID: 18471351
  71. Data suggest that augmented vascular reactivity in male hypertensive rats is mediated via activation of the ERK1/2 pathway, and mitogen-activated protein kinase phosphatase 1 and interleukin 10 play regulatory roles in this process. PMID: 19901158
  72. the expressed IL-10 is a causal factor in the protection from endotoxemia PMID: 11900340
  73. Inhibition of microglial CD40 expression by pituitary adenylate cyclase-activating polypeptide is mediated by interleukin-10. PMID: 12020953
  74. REVIEW: Endogenous generation of IL- 10 and IL- 13 as well as secretory leukocyte protease inhibitor (SLPI), significantly regulates the inflammatory response PMID: 12162438
  75. IL-10, produced by activated microglial and astroglial cells, modulates glia-mediated inflammatory responses through high-affinity IL-10 receptors via paracrine and autocrine interactions PMID: 12405978
  76. Kupffer cells after hepatectomy may aggravate endotoxin-induced liver injury via down-regulation of IL-10 production in the spleen. PMID: 12547408
  77. findings suggest that endogenous IL-10 plays a regulatory role in the development of experimental obliterative bronchiolitis PMID: 12565791
  78. glial cell line-derived neurotrophic factor (GDNF) and IL-10 are mesangial autocrine growth factors that play a pivotal role in rat mesangial cell proliferation in vitro. PMID: 12595497
  79. Crucial regulatory role for endogenous IL-10 in limiting the fever responses during both Gram-negative and Gram-positive infections. PMID: 12692173
  80. IL-10 prevents tissue injury during intestinal reperfusion injury by mediating the protective effects of IL-1 beta. PMID: 12707357
  81. IL-10 production by Kupffer cells early after trauma-hemorrhage may play a pivotal role in attenuating the proinflammatory cytokine environment, possibly in an autocrine/paracrine manner. PMID: 14715528
  82. IL-10 gene transfer significantly attenuated the glomerular lesions and injury in the anti-GBM crescentic glomerulonephritis of Wistar-Kyoto rats. PMID: 15086467
  83. Primary hepatocytes co-cultured with LPS-stimulated Kupffer cells or cultured with a combination of IL-1beta and IL-10 displayed reduced levels of phosphoenolpyruvate carboxykinase mRNA, protein and enzyme activity PMID: 15147725
  84. Increased expression of IL-10 in islets of langerhans after brain death. PMID: 15251379
  85. IL-10 may promote the apoptosis of hepatic stellate cells by up-regulating the expressions of FasL and Bax and down-regulating the expression of Bcl-2, which may be involved in its antifibrosis mechanism. PMID: 15309723
  86. TNF-alpha, IL-10, and IL-6 production in Kupffer cells following LPS or lipoteichoic acid stimulation may create a basis for understanding how the balance between pro- and antiinflammatory cytokines is regulated in the liver following bacterial infections PMID: 15385469
  87. IL-10 exhibits an antifibrogenic effect in liver fibrosis by suppressing MMP-2 and TIMP-1 expression. PMID: 15793858
  88. dendritic cells activated CD4(+) T cells to produce interferon (IFN)-gamma, IL-4, and IL-10 PMID: 16002150
  89. IL-10 may act as an autocrine growth factor for cells with metastatic phenotype in rat b-cell lymphoma; up-regulation of IL-10 and IL-10R expression part of transition from primary tumor to metastatic phenotype PMID: 16086233
  90. inhibits bone resorption by up-regulating osteoprotegerin expression while down-regulating expression of nuclear factor-kappa B ligand and colony-stimulating factor-1 PMID: 16460340
  91. This study suggests that a decrease in IL-10 and IL-10-to-TNF-alpha ratio correlates with depressed cardiac function. PMID: 16461369
  92. Data show strong expression of interleukins (IL)-4, IL-10, and IL-13 in different non-leukocytic cell types, especially in endothelial and epithelial cells in the rat, with strong similarity of expresion in humans. PMID: 16522370
  93. Might play a role in protective effect from renal reperfusion injury of administration of low doses of lipopolysaccharide. PMID: 16670641
  94. Intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control. PMID: 16949747
  95. The expression of Fas and FasL increased in the course of the liver fibrosis, and would be furthered by IL-10. The IL-10 could cause the apoptosis of activated hepatic stellate cells. PMID: 17105443
  96. Intrathecal IL-10 gene therapy both prevented, and progressively reversed, paclitaxel-induced allodynia, increased IL-10 mRNA levels in lumbar dorsal root ganglia and meninges, and decreased paclitaxel-induced expression of IL-1, TNF, and CD11b mRNA. PMID: 17174526
  97. gp96 can act as a costimulatory molecule for CD3+ T cells, and an observed increase in the IL-10: IFN-gamma secretion ratio induced by gp96 suggests that it might, at appropriate concentrations, promote a regulatory T-helper 2 (Th2)-like phenotype. PMID: 17278885
  98. These results suggest that the significant change in IL-10 occurred prior to the significant change in TNF and that IL-10 may be the key to the change in TNF. PMID: 17336456
  99. Interleukin-10 at a concentration of 1 ng/ml completely eliminated the development of epileptiform activity, while its protective effect was less marked at a concentration of 10 ng/ml. PMID: 17505796
  100. The marked up-regulation of nerve growth factor and interleukin-10 in colitis suggests that they play a role in limiting or resolving inflammation and in preventing it from becoming uncontrolled. PMID: 17517520

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Subcellular Location Secreted
Protein Families IL-10 family
Database Links

KEGG: rno:25325

STRING: 10116.ENSRNOP00000006246

UniGene: Rn.9868

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