Rat Interleukin 10,IL-10 ELISA KIT

1. Low IL10 expression is associated with liver fibrosis. PMID: 30243650
2. A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti-secretary, mucoprotective and IL-10 mediated anti-inflammatory mechanisms. PMID: 29924982
3. IL10 suppressed inflammation, facilitated retinal pigment epithelium cell apoptosis and inhibited cell proliferation and migration through the regulation of VEGF expression in rhegmatogenous retinal detachment. PMID: 29568872
4. ghrelin with high doses (80 and 160 mug/kg) significantly reduced pain intensity in both the early and the late phases of pain. The serum levels of cytokines, IL-10, and TGF-beta1 showed a significant elevation with ghrelin at the dose of 160 mug/kg. PMID: 27703278
5. IL-10 not only attenuates neuronal apoptosis, but also promotes neurite outgrowth and synapse formation via the JAK1/STAT3 signaling pathway. PMID: 27456198
6. both the AV and the LV vector systems were able to transfect limbal graft tissue ex vivo with biologically active IL-10, leading to delayed rejection compared to the controls. PMID: 28925732
7. Addition of 320 (48) and 640 (96) mg/L (mg/kg BW) boron markedly reduced the serum IgG concentrations; splenic IL-2 and IL-10 expression; the number of CD3(+), CD4(+) and PCNA(+) cells; and increased the number of splenic CD8(+) and caspase-3(+) cells and promoted caspase-3 expression in CD3(+) cells. PMID: 28092075
8. The expression levels of IL-10, NF-kappaB and MMP-3 in the intervertebral disc tissue samples were higher in test animals than in controls at one-month, three-months and six-months after surgically induced cervical spondylosis. Cervical degeneration may be accompanied by changes in IL-10. PMID: 29197741
9. Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti-Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta-Carotene, and Spirulina fusiformis: Role of NF-kappaB, iNOS, IL-6, and IL-10.( PMID: 28387444
10. the effects of dapagliflozin on STAT3 activity and myocardial IL-10 levels can be reversed by 3-morpholinosydnonimine, a peroxynitrite generator. Taken together, these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling PMID: 28132924
11. TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. PMID: 28258441
12. this study shows that transduction of interleukin-10 through renal artery attenuates vascular neointimal proliferation and infiltration of immune cells in rat renal allograft PMID: 27317647
13. this study shows that that N-Acetyl-l-cysteine acts as an antipyretic via IL-10 stimulation PMID: 27363620
14. Transplantation of mesenchymal stem cells overexpressing IL10 preserves myocardial viability and left ventricular rfunction in rats with myocardial infarction. PMID: 28322445
15. The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge PMID: 28686630
16. use of rebamipide retards CCl4-induced hepatic fibrosis, which is associated with significant increases in liver levels of IL-10 PMID: 26849241
17. Data suggest that vitamin A, when used as an unnecessary dietary supplement, decreases skeletal muscle expression of anti-inflammatory mediators interleukin-10 and heat shock protein 70, important factors for positive exercise adaptations and tissue damage prevention. PMID: 28368329
18. Exercise combined with ultrasound attenuates neuropathic pain in rats and is associated with downregulation of IL-6 and TNF-alpha, and with upregulation of IL-10. PMID: 28319508
19. Results uncover a novel neuroimmune modulation of GABAergic neurotransmission as well as a novel role for IL-10 in response to acute ethanol intake. Early increase in IL-10 levels may contribute to the complex changes in neuroimmune signaling that occur after acute exposure to ethanol. Further, IL-10 has an inhibitory effect on GABAergic transmission, possibly leading to inhibition of sleep PMID: 27016017
20. Nonsteroidal Anti-Inflammatory Drugs data provide opportunities to investigate such associations and specifically imply that potential interrelationships among OTC NSAID use, IL-10 genotype, and IL-10 cytokine levels deserve further study PMID: 28135825
21. The expression of IL-10 and TGF-beta in the CD25 siRNA group increased, while IFN-gamma, IL-1beta, and TNF-alpha expression decreased, as well as no significant changes in Foxp3 expression were observed at day 14 post-operation. PMID: 27567557
22. IL10 has a role in preventing -induced cell death in rat hippocampal cultures PMID: 28063948
23. IL-10 592 polymorphism was associated with diabetic retinopathy susceptibility, suggesting that the gene polymorphism might be a risk factor for diabetic retinopathy PMID: 26492380
24. Mesenchymal stromal cells inhibit Human antigen R (HuR) trascription, an enhancer of RENmRNA stability by IL10 release PMID: 26866372
25. Mesenchymal stem cells decrease apoptosis and improve learning-memory function in hypoxic-ischemic brain damage rats by suppressing the TLR2/NFkappaB signaling pathway via a feedback mechanism that reduces IL-10 release. PMID: 26475712
26. Green tea intake reduces expression of the pro-inflammatory cytokine TNF-alpha and the osteoclastogenic mediator RANKL to normal levels while increasing expression of the anti-inflammatory cytokine IL-10. PMID: 26270535
27. IL-10 released from activated glial cells in the VLO can potentially attenuate allodynia while IL-1beta released from activated glial cells in the VLO can potentially maintain or facilitate allodynia PMID: 25617163
28. The objectives of these studies were to investigate the responses of IL-10 receptors (IL-10Rs) and IL-10 signalling proteins (IL-10SPs) in hyperoxic foetal alveolar type II cells. PMID: 26059905
29. Leydig cell-conditioned media dose-dependently stimulated expression of transcription factor Foxp3 and secretion of IL-10 in splenic CD4+ T cells, an effect abolished by addition of the anti-androgen flutamide. PMID: 25598450
30. Exercise increased the amount of IL-1beta and IL-10 positive chondrocytes PMID: 25702530
31. Study shows that, in addition to inducing persistent memory deficits, maternal deprivation increased the levels of the anti-inflammatory cytokine, IL-10, and of the pro-inflammatory cytokine, TNF-alpha, and decreased the levels of BDNF in the adulthood PMID: 25182413
32. atropine in malathion intoxicated rats had no effect on suppression of the synthesis of proinflammatory cytokines TNF, IL-1g and IL-6 as well as the content of anti-inflammatory cytokines IL-10 and IL-13. PMID: 26591203
33. Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF-alpha. PMID: 25096025
34. the preserved ability of macrophages from aged AO rats to synthesize not only proinflammatory TNF-alpha, but also immunoregulatory IL-10 cytokine most likely contributes to their longer average life compared with DA rats PMID: 25009084
35. The dysfunction of dendritic cells and the increase of IL-10-producing Breg and Foxp3(+) Treg might play important roles in hepatocellular carcinoma progression PMID: 25066760
36. SOCS-3 was involved in cerebral vasospasm after subarachnoid hemorrhage via an IL-6- and IL-10-related mechanism. IL-10 levels increased during the first 6 h after SAH, after which this increase tapered off. PMID: 24463741
37. results suggest that IL-10/HMOX1 signaling is involved in modulation of cochlear inflammation through inhibition of MCP-1/CCL2 regulation in SLFs PMID: 25780042
38. The neuronal apoptosis rate was positively correlated with the levels of TNF-alpha and IL-6, and negatively correlated with IL-10 and GDNF. PMID: 24706318
39. cells from long-lived rats exhibited a dramatic increase in IL-10 mRNA expression followed by diminished TNF-alpha and IL-6 mRNA expression, and comparable expression of IL-1beta mRNA relative to adult rats. PMID: 25081109
40. Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10. PMID: 25329858
41. Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury PMID: 25471580
42. We found cardiac and histological changes compatible with the inflammatory process triggered by acute pancreatitis with the promotion of local myocardial cytokine production. PMID: 24865534
43. study provides novel evidence that IL-10 plays an up-regulatory role in the anti-hypertensive activity of CCL5 in SHR VSMCs PMID: 24656930
44. The high expression in IL-1beta and IL-10 levels in small bowel and colon might explain the accelerated healing process in these wounds in comparison to skin and muscle tissues. PMID: 24114903
45. Daily treatment with anti-IL10 antibody significantly increased paw edema. PMID: 23765634
46. Prevention of acute liver allograft rejection by IL-10-engineered mesenchymal stem cells. PMID: 24527865
47. Gemfibrozil plus metformin decrease MMP-9, increase IL-10 and adiponectin acting. PMID: 23111552
48. Pro-inflammatory cytokines from area postrema and organum vasculosum laminae terminalis are modulated by IL-10 antibodies. PMID: 23388469
49. GSK-3beta modulates inflammatory IL-10 levels released from cortical glia. PMID: 22796213
50. These data in cardiomyocytes suggest that IL-10 induced anti-apoptotic signaling involves upregulation of TLR4 through MyD88 activation. PMID: 23141143
51. some evidence about existence of the novel mechanism underlying the rapid neuroprotective effect of anti-inflammatory cytokine IL-10 against hypoxia-induced neurological deteriorations. PMID: 23178472
52. IL-10 blocks the angiotensin II-induced decrease in delayed rectifier K+ current, a result consistent with a direct inhibitory action of interleukin-10 on angiotensin-II induced excitation of hypothalamic neurons. PMID: 23426971
53. MicroRNA-27a regulates cardiomyocytic apoptosis during cardioplegia-induced cardiac arrest by targeting interleukin 10-related pathways. PMID: 23143062
54. Animals inoculated with herpes simplex virus (HSV)-based gene transfer vector vIL10) have a statistically significant reduction in level of neuropathic pain after traumatic spinal cord injury compared to injured rats. PMID: 22593113
55. High IL-10 expression is associated with B-cell lymphoma. PMID: 23185784
56. Glutamate significantly increases lipopolysaccharide-stimulated IL-10 release from astrocytes by 166% and significantly upregulates IL-10 mRNA levels. PMID: 22326966
57. Changes of IL-10 protein in dorsal root ganglia (DRG) nonassociated with damaged nerve could be related to a general neuroinflammatory reaction of the nervous system to injury and thereby promote potential of DRG neurons for regenerating their axons. PMID: 21763399
58. Glutamate substantially increases the release of anti-inflammatory cytokine IL-10 (but not IL-1beta release) activated by a high concentration of lipopolysaccharide. PMID: 21081156
59. RhoA can aggravate the pathology changes of ALI rats, which might be related to up regulating expression of IL-8 and down regulating expression of IL-10 by RhoA. PMID: 22152812
60. Cobalt protoporphyrin can up-regulate HO-1 expression in bone marrow-derived mesenchymal stem cells, which increases IL-10 secretion significantly. PMID: 21129280
61. connection of NO/IL-10/PECAM-1 during in vivo inflammatory conditions elicited by LPS has been shown PMID: 21564091
62. Osmotic pump infusion of IL-10 in rats protected against LPS-induced cell death of dopaminergic neurons suggesting that the reduction in microglia-mediated release of inflammatory mediators may contribute to the anti-inflammatory effect of IL-10. PMID: 21887889
63. data indicate that under the influence of the testicular environment, macrophages adopt an alternatively activated phenotype, involving reduced capacity for proinflammatory gene expression, constitutive IL-10 production PMID: 21498587
64. Increased interleukin 10 is associated with reduced cardiac function in rats following coronary microembolization. PMID: 20625799
65. IL-6 and IL-10 are important physiological contributors to the central insulin and leptin action mediated by physical activity, linking it to hypothalamic ER stress and inflammation. PMID: 20808781
66. The rise of the selective cardioinhibitory cytokines may be interpreted as the adaptive response of jeopardized myocardium to the cardiac dysfunction resulting from MDMA injection. PMID: 20420568
67. Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 expression in rat brain. PMID: 20193756
68. Evidence supports the ability of central IL-10 to attenuate peripheral lipopolysaccharide (LPS)-induced changes in food intake and energy expenditure as well as the neurochemical and inflammatory consequences of LPS. PMID: 20045008
69. Data describe the effect of exercise in rats with heart failure after post-myocardial infarction, with regard to expression of TNF-alpha and IL-10 in the soleus and extensor digitorum longus (EDL), muscles with different fiber composition. PMID: 19948415
70. IL-10 plays an important role in CD4(+)CD25(+) T cell inducing immune tolerance of allogeneic liver transplantation. PMID: 18471351
71. Data suggest that augmented vascular reactivity in male hypertensive rats is mediated via activation of the ERK1/2 pathway, and mitogen-activated protein kinase phosphatase 1 and interleukin 10 play regulatory roles in this process. PMID: 19901158
72. the expressed IL-10 is a causal factor in the protection from endotoxemia PMID: 11900340
73. Inhibition of microglial CD40 expression by pituitary adenylate cyclase-activating polypeptide is mediated by interleukin-10. PMID: 12020953
74. REVIEW: Endogenous generation of IL- 10 and IL- 13 as well as secretory leukocyte protease inhibitor (SLPI), significantly regulates the inflammatory response PMID: 12162438
75. IL-10, produced by activated microglial and astroglial cells, modulates glia-mediated inflammatory responses through high-affinity IL-10 receptors via paracrine and autocrine interactions PMID: 12405978
76. Kupffer cells after hepatectomy may aggravate endotoxin-induced liver injury via down-regulation of IL-10 production in the spleen. PMID: 12547408
77. findings suggest that endogenous IL-10 plays a regulatory role in the development of experimental obliterative bronchiolitis PMID: 12565791
78. glial cell line-derived neurotrophic factor (GDNF) and IL-10 are mesangial autocrine growth factors that play a pivotal role in rat mesangial cell proliferation in vitro. PMID: 12595497
79. Crucial regulatory role for endogenous IL-10 in limiting the fever responses during both Gram-negative and Gram-positive infections. PMID: 12692173
80. IL-10 prevents tissue injury during intestinal reperfusion injury by mediating the protective effects of IL-1 beta. PMID: 12707357
81. IL-10 production by Kupffer cells early after trauma-hemorrhage may play a pivotal role in attenuating the proinflammatory cytokine environment, possibly in an autocrine/paracrine manner. PMID: 14715528
82. IL-10 gene transfer significantly attenuated the glomerular lesions and injury in the anti-GBM crescentic glomerulonephritis of Wistar-Kyoto rats. PMID: 15086467
83. Primary hepatocytes co-cultured with LPS-stimulated Kupffer cells or cultured with a combination of IL-1beta and IL-10 displayed reduced levels of phosphoenolpyruvate carboxykinase mRNA, protein and enzyme activity PMID: 15147725
84. Increased expression of IL-10 in islets of langerhans after brain death. PMID: 15251379
85. IL-10 may promote the apoptosis of hepatic stellate cells by up-regulating the expressions of FasL and Bax and down-regulating the expression of Bcl-2, which may be involved in its antifibrosis mechanism. PMID: 15309723
86. TNF-alpha, IL-10, and IL-6 production in Kupffer cells following LPS or lipoteichoic acid stimulation may create a basis for understanding how the balance between pro- and antiinflammatory cytokines is regulated in the liver following bacterial infections PMID: 15385469
87. IL-10 exhibits an antifibrogenic effect in liver fibrosis by suppressing MMP-2 and TIMP-1 expression. PMID: 15793858
88. dendritic cells activated CD4(+) T cells to produce interferon (IFN)-gamma, IL-4, and IL-10 PMID: 16002150
89. IL-10 may act as an autocrine growth factor for cells with metastatic phenotype in rat b-cell lymphoma; up-regulation of IL-10 and IL-10R expression part of transition from primary tumor to metastatic phenotype PMID: 16086233
90. inhibits bone resorption by up-regulating osteoprotegerin expression while down-regulating expression of nuclear factor-kappa B ligand and colony-stimulating factor-1 PMID: 16460340
91. This study suggests that a decrease in IL-10 and IL-10-to-TNF-alpha ratio correlates with depressed cardiac function. PMID: 16461369
92. Data show strong expression of interleukins (IL)-4, IL-10, and IL-13 in different non-leukocytic cell types, especially in endothelial and epithelial cells in the rat, with strong similarity of expresion in humans. PMID: 16522370
93. Might play a role in protective effect from renal reperfusion injury of administration of low doses of lipopolysaccharide. PMID: 16670641
94. Intrathecal IL-10 gene therapy may provide a novel approach for prolonged clinical pain control. PMID: 16949747
95. The expression of Fas and FasL increased in the course of the liver fibrosis, and would be furthered by IL-10. The IL-10 could cause the apoptosis of activated hepatic stellate cells. PMID: 17105443
96. Intrathecal IL-10 gene therapy both prevented, and progressively reversed, paclitaxel-induced allodynia, increased IL-10 mRNA levels in lumbar dorsal root ganglia and meninges, and decreased paclitaxel-induced expression of IL-1, TNF, and CD11b mRNA. PMID: 17174526
97. gp96 can act as a costimulatory molecule for CD3+ T cells, and an observed increase in the IL-10: IFN-gamma secretion ratio induced by gp96 suggests that it might, at appropriate concentrations, promote a regulatory T-helper 2 (Th2)-like phenotype. PMID: 17278885
98. These results suggest that the significant change in IL-10 occurred prior to the significant change in TNF and that IL-10 may be the key to the change in TNF. PMID: 17336456
99. Interleukin-10 at a concentration of 1 ng/ml completely eliminated the development of epileptiform activity, while its protective effect was less marked at a concentration of 10 ng/ml. PMID: 17505796
100. The marked up-regulation of nerve growth factor and interleukin-10 in colitis suggests that they play a role in limiting or resolving inflammation and in preventing it from becoming uncontrolled. PMID: 17517520

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KEGG: rno:25325

STRING: 10116.ENSRNOP00000006246

UniGene: Rn.9868