Function
(From Uniprot) |
Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
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| Gene References into Functions |
- The results of the present study indicated that maternal undernutrition during pregnancy may lead to an increase in hepatic triglycerides, via alterations in the transcriptional and epigenetic regulation of the LPL gene. PMID: 27035287
- Cardiomyocyte VEGF activates EC Notch signaling, facilitating GPIHBP1-mediated translocation of LPL across EC and regulating LPL-derived fatty acid delivery to the cardiomyocytes. PMID: 26586663
- the amount of LPL expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue. PMID: 25589507
- Data indicate that oxidation of oleic acid was reduced by 50% in lipoprotein lipase LPL-knock-down (LPL-KD) cells compared to wild-type (WT) cells. PMID: 25931001
- Activated cyclin-dependent kinase 5 promotes microglial phagocytosis of fibrillar beta-amyloid by up-regulating lipoprotein lipase expression PMID: 23816988
- Suggest that the heparanase-lipoprotein lipase-VEGF axis amplifies fatty acid delivery, a rapid and adaptive mechanism that is geared to overcome the loss of glucose consumption by the diabetic heart. PMID: 24115032
- The plasticity of the LPL system is severely blunted or completely lost in insulin resistant rats. PMID: 23176178
- active heparanase released lipoprotein lipase from the myocyte surface PMID: 23471235
- Data suggest that endothelial lipoprotein lipase (LPL) levels in the heart are altered to maintain FA flux and may exploit angiopoietin-like protein-4 (ANGPTL4). PMID: 22226882
- Report a simple procedure for measuring lipoprotein lipase activity. PMID: 22870821
- In acute hyperglycemia and moderate diabetes, exaggerated LPL processing to dimeric, catalytically active enzyme increases coronary LPL, delivering more FA to the heart when glucose utilization is compromised. PMID: 21646389
- This study showed that adiponectin mediates actin cytoskeleton remodeling to translocate lipoprotein lipase and allow subsequent activation. PMID: 21147877
- When compared with obesity-resistant rats, the gene expression of LPL was higher in obesity-prone rats. PMID: 17712951
- The over-expression of LPL in the hippocampus may play an important role in the oxidative stress mechanisms following status epilepticus (SE) by regulating the uptake of vitamin E. PMID: 20497648
- Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on PMID: 11809775
- An HFS diet induces changes in LPL and VLDL-R in a manner which favors shunting of dietary fat from skeletal muscle to adipose tissue. PMID: 11882325
- characterized changes in LPL activity in adipose tissue and muscles before and during the early phase of obesity development in the JCR:LA-cp rat PMID: 11896485
- STZ-induced diabetes causes a decrease in LPL activity in the sciatic nerve that is reversible with insulin treatment PMID: 11897675
- insulin deficiency impairs the expression of LPL in mammary glands, revealing the role of insulin as a modulator of the enzyme at the mRNA expression level PMID: 11900280
- The hormonal responses of LPL activity and lipolysis in adipose tissue differed depending on the stage of the estrous cycle. PMID: 12032743
- Although Lpl increases arterial wall accumulation of triglyceride-rich particles(TGRPs), it also reduces the penetration of TGRPs into the arterial wall--a novel antiatherogenic property. PMID: 12482838
- PPAR-gamma activation mediates adipose depot-specific effects on gene expression and activity of this enzyme. PMID: 12540599
- the nutritional regulation of LPL in adipose tissue determines the activity state of extracellular LPL. PMID: 12551943
- the striking sensitivity of muscle lipoprotein lipase to inactivity and low-intensity contractile activity may indicate why inactivity is a risk factor for metabolic diseases PMID: 12815182
- Rapid "metabolic switching" occurs through Lpl occupation of endothelial binding-sites. PMID: 12967632
- AMPK-mediated recruitment of LPL to the coronary lumen could represent an immediate compensatory response by the heart to guarantee fatty acid supply. PMID: 15328075
- The decrease of LPL mass and activity that occurs when explants of rat adipose tissue are incubated is due to proteolysis of extracellular LPL. The effect of inhibitors indicates, but does not prove, that the degradation is mediated by MMPs. PMID: 15670333
- Lysophosphatidic acid induced increases in cardiac lipoprotein lipase occurred via posttranscriptional mechanisms and processes. PMID: 15681706
- Upregulated by rosiglitazone PMID: 15887043
- Chronic stress decreased LPL in mesenteric and epididymal white adipose tissue(WAT). Acute stress decreased LPL only in retroperitoneal WAT and increased LPL in preheparin plasma active LPL. PMID: 15947029
- The finding that nephrotic serum alters lipoprotein lipase (LpL) binding to rat aortic endothelial cells suggests LpL depletion results from decreased binding rather than defective delivery. PMID: 16807550
- Angiopoietin-like protein 4 is a fasting-induced controller of lipoprotein lipase in adipose tissue, acting extracellularly on the native conformation in an unusual fashion, like an unfolding molecular chaperone PMID: 17088546
- Accelerated triglyceride clearance was associated with increased Lpl activity, mostly in brown adipose tissue. PMID: 17170230
- the release from endothelium to the bloodstream may constitute a fast nonexplored mechanism of tissue LPL activity regulation, involved in the lipid energy-substrate redistribution between tissues needed to prepare the "fight-or-flight" respo PMID: 17259660
- hormonal and nutritional induction of liver PPAR-alpha expression around birth and its maintained elevated level throughout suckling is responsible for the induction of liver LPL-expression and activity during suckling PMID: 17451160
- Suggest the involvement of brain phosphatidylinositol-specific PLC and diacylglycerol lipase in the centrally administered histamine-induced activation of the adrenomedullary outflow in rats. PMID: 17628524
- oxidized fat impairs normal metabolic adaptations during lactation, which promote the utilization of metabolic substrates by the mammary gland for the synthesis of milk PMID: 17709442
- Administration of resistin to adipocytes mimicked the effects of GIP on the PKB/LKB1/AMPK/LPL pathway: increasing phosphorylation of PKB, reducing levels of phosphorylated LKB1 and AMPK, and increasing LPL activity. PMID: 17890220
- Recruitment of LPL to the cardiomyocyte surface represents an immediate compensatory response by the heart to guarantee fatty acid supply when glucose utilization is compromised. PMID: 17942824
- after diabetes, Protein kinase D control of LPL requires dissociation of Hsp25 from PKCdelta, association between PKCdelta and PKD, and vesicle fission. PMID: 18583709
- Cold acclimation significantly increased heparin-releasable LPL (P<0.05) and tissue residual LPL (P<0.01)in the heart. AMPK phosphorylation does not mediate the enhanced translocation of LPL to cardiac endothelium. PMID: 18722549
- Epididymal white adipose tissue perfused in situ with an nitric oxide donor rapidly releases LPL from the endothelium. PMID: 19088434
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