Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein(BTC) (Active)

In Stock
Code CSB-AP002871HU
Product Type Growth Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P35070
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered PBS, pH 7.4, with 0.02 % Tween-20 ,lyophilized
Alias BTC
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x107 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Signal Transduction
Source E.coli
Gene Names BTC
Expression Region 32-111aa
Tag Info Tag-Free
Mol. Weight 9.0 kDa
Protein Description Partial
PubMed ID 8439318; 15489334; 8144591; 8919026; 8570211; 10867024; 12074582
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Function Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular Location Betacellulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Probetacellulin: Cell membrane, Single-pass type I membrane protein
Tissue Specificity Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
Database Links

HGNC: 1121

OMIM: 600345

KEGG: hsa:685

STRING: 9606.ENSP00000379092

UniGene: Hs.591704

Pathway ErbB signaling pathway

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