Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein(BTC) (Active)

Code CSB-AP002871HU
Product Type Growth Factor
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P35070
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4, with 0.02 % Tween-20 ,lyophilized
Alias BTC
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0x107 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
Research Area Signal Transduction
Source E.Coli
Gene Names BTC
Expression Region 32-111aa
Product Info Tag-Free
Mol. Weight 9.0 kDa
Protein Description Partial
PubMed ID 8439318; 15489334; 8144591; 8919026; 8570211; 10867024; 12074582
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Function Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Subcellular location Betacellulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Probetacellulin: Cell membrane, Single-pass type I membrane protein
Pathway ErbB signaling pathway

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