FILIP1L Monoclonal Antibody

Code CSB-MA679703A0m
Size US$350 How to order?
  • Western Blot
    Positive WB detected in: 293 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
    All lanes: FILIP1L antibody at 1:1000
    Goat polyclonal to mouse IgG at 1/50000 dilution
    Predicted band size: 102 kDa
    Observed band size: 29, 80, 102, 130 KDa
    Exposure time:5min
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Product Details

Full Product Name Mouse anti-Homo sapiens (Human) FILIP1L Monoclonal Antibody antibody
Uniprot No. Q4L180
Target Names FILIP1L
Alternative Names 130 kDa GPBP-interacting protein antibody; 90 kDa GPBP-interacting protein antibody; COL4A3BPIP antibody; DOC-1 antibody; DOC1 antibody; Downregulated in ovarian cancer 1 81 kDa isoform antibody; FIL1L_HUMAN antibody; Filamin A-interacting protein 1-like antibody; FILIP1L antibody; GIP130 antibody; GIP130a antibody; GIP130b antibody; GIP130c antibody; GIP90 antibody; GPBP interacting protein 90 antibody; Protein down-regulated in ovarian cancer 1 antibody
Raised in Mouse
Species Reactivity Human
Immunogen Recombinant Human Filamin A-interacting protein 1-like protein (1-200AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal Antibody
Isotype IgG1
Clone No. 4H7G5
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.
Gene References into Functions
  1. FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. PMID: 27750216
  2. Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival. PMID: 27776341
  3. these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis PMID: 24327474
  4. down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers. PMID: 24340050
  5. these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy. PMID: 21693594
  6. a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system. PMID: 21784850
  7. DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells PMID: 15935955

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Subcellular Location Cytoplasm. Membrane. Nucleus.
Protein Families FILIP1 family
Tissue Specificity Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. D
Database Links

HGNC: 24589

OMIM: 612993

KEGG: hsa:11259

STRING: 9606.ENSP00000346560

UniGene: Hs.104672

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