FILIP1L Monoclonal Antibody

1. FILIP1L inhibits progression in colorectal cancer by inhibiting tumor cell proliferation and angiogenesis. PMID: 27750216
2. Studies have shown that FILIP1L expression is related with inhibition of metastases and chemoresistance of ovarian neoplasm, which is associated with downregulation of EMT through beta-catenin degradation. FILIP1L expression correlates with significantly improved overall survival. PMID: 27776341
3. these findings suggest that FILIP1L reduces beta-catenin levels, which may lead to the transcriptional downregulation of WNT target genes such as MMPs, resulting in inhibition of metastasis PMID: 24327474
4. down-regulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in various cancers. PMID: 24340050
5. these findings suggest that downregulation of FILIP1L associated with DNA methylation is related with the invasive phenotype in ovarian cancer and that modulation of FILIP1L expression has the potential to be a target for ovarian cancer therapy. PMID: 21693594
6. a novel function for FILIP-1L and a pathway for Hsf1 degradation through the ubiquitin-proteasome system. PMID: 21784850
7. DOC1 might play a role in mediating some of the effects of EMAP-II on endothelial cells PMID: 15935955

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HGNC: 24589

OMIM: 612993

KEGG: hsa:11259

STRING: 9606.ENSP00000346560

UniGene: Hs.104672