HAO1 Monoclonal Antibody

Code CSB-MA080172
Size US$119
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  • Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Monoclonal Antibody.
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Product Details

Uniprot No.
Target Names
HAO1
Alternative Names
(S) 2 hydroxy acid oxidase antibody; Glycolate oxidase antibody; GOX antibody; GOX1 antibody; HAO1 antibody; HAOX1 antibody; HAOX1_HUMAN antibody; Hydroxyacid oxidase 1 antibody; MGC142225 antibody; MGC142227 antibody; OTTHUMP00000030231 antibody
Raised in
Mouse
Species Reactivity
Mouse,Rat
Immunogen
Recombinant Protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Clone No.
10D9
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
Gene References into Functions
  1. The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase. PMID: 21141873
  2. The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues. PMID: 20054120
  3. These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme. PMID: 17669354
  4. Active site and loop 4 movements within human glycolate oxidase. PMID: 18215067
Subcellular Location
Peroxisome.
Protein Families
FMN-dependent alpha-hydroxy acid dehydrogenase family
Tissue Specificity
Liver.
Database Links

HGNC: 4809

OMIM: 605023

KEGG: hsa:54363

STRING: 9606.ENSP00000368066

UniGene: Hs.193640

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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