Code | CSB-MA550667 |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
This monoclonal antibody specifically against human KRT5 protein was produced using hybridoma technology. First, mice were immunized with a synthesized peptide derived from human KRT5, and then B cells were isolated from their spleen. The B cells were fused with myeloma cells to form hybridomas, from which those continuously produce the KRT5 antibody was screened and selected. The KRT5 antibody-secreting hybridomas were cultured in the mouse abdominal cavity. The purified KRT5 monoclonal antibody was obtained from mouse ascites using a specific immunogen. This KRT5 monoclonal antibody has been validated in ELISA and IHC applications.
KRT5 is a type II intermediate filament protein that is primarily expressed in the basal cells of stratified epithelia, including the epidermis of the skin, hair follicles, and nails. KRT5 functions to provide structural support and integrity to these tissues by forming a cytoskeletal network of filaments. It also plays a role in cell signaling pathways and gene regulation. Mutations in the KRT5 gene have been associated with several skin disorders, including epidermolysis bullosa simplex and Dowling-Degos disease.
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