Code | CSB-MA949708 |
Size | US$166 |
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Application | Recommended Dilution |
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IHC | 1:20-1:200 |
The production of the KRT6A monoclonal antibody involves the use of hybridoma technology. To obtain this KRT6A monoclonal antibody, B cells were isolated from the spleen of a mouse immunized with the synthesized peptide derived from human KRT6A and then fused with myeloma cells to create hybridoma cells. Hybridomas that secreted KRT6A antibodies were screened and then injected into the abdominal cavity of mice for culture. The resulting KRT6A monoclonal antibody was then purified from mouse ascites through affinity chromatography, using a specific immunogen, to ensure its purity. The purified KRT6A monoclonal antibody is suitable for use in ELISA and IHC applications and has been validated for its specificity towards human KRT14 protein.
KRT6A is specifically expressed in hair follicles, nails, and other keratinized epithelial tissues. It plays a key role in the formation and maintenance of hair shafts and is involved in hair growth and differentiation. Additionally, KRT6A has been implicated in wound healing and the response to various stresses, such as heat shock and oxidative stress. Mutations in KRT6A have been associated with hair disorders, such as pachyonychia congenita.
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