Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein(GPD1L),Escherichia Coli

Code CSB-EP854029HU
Product Type Recombinant Protein
Size EP: USD1273
Uniprot No. Q8N335
Abbreviation GPD1L
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity >85% (SDS-PAGE)
Sequence MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR KLTDIINNDH ENVKYLPGHK LPENVVAMSN LSEAVQDADL LVFVIPHQFI HRICDEITGR VPKKALGITL IKGIDEGPEG LKLISDIIRE KMGIDISVLM GANIANEVAA EKFCETTIGS KVMENGLLFK ELLQTPNFRI TVVDDADTVE LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF ARIFCKGQVS TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQEM LSCLQSHPEH T
Source E.coli
Gene Names Name:GPD1L Synonyms:KIAA0089
Protein Names Recommended name: Glycerol-3-phosphate dehydrogenase 1-like protein Short name= GPD1-L EC= 1.1.1.8
Expression Region 1-351
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
Protein Description full length protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Involvement in disease Brugada syndrome 2 (BRGDA2); Sudden infant death syndrome (SIDS)
Subcellular Location Cytoplasm
Protein Families NAD-dependent glycerol-3-phosphate dehydrogenase family
Tissue Specificity Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
Database Links

HGNC: 28956

OMIM: 272120

KEGG: hsa:23171

STRING: 9606.ENSP00000282541

UniGene: Hs.82432

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