GPD1L

GPD1L, located on chromosome 3 at the 3p22.3 locus, encodes an enzyme responsible for converting sn-glycerol-3-phosphate into glycerophosphate. This enzyme is broadly expressed across various tissues, with notable presence in the heart and prostate. Linked to the regulation of apoptosis, GPD1L's overexpression has been shown to suppress renal clear cell carcinoma progression by triggering apoptosis. Furthermore, GPD1L is implicated in the transport function of the Na+ channel in cardiomyocytes, with mutations potentially leading to Brugada syndrome. The enzyme plays a significant role not only in tumor development but also in cellular metabolism and apoptosis, suggesting its broader impact on the genesis of various diseases.