Greater than 95% as determined by SDS-PAGE.
Less than 1.0 EU/ug as determined by LAL method.
Measured by its binding ability in a functional ELISA. Immobilized Human DSG3 at 2 μg/mL can bind Anti-DSG3 recombinant antibody (CSB-RA007205A0HU), the EC50 is 4.552-5.720 ng/mL.
(130 kDa pemphigus vulgaris antigen)(PVA)(Cadherin family member 6)
Homo sapiens (Human)
Target Protein Sequence
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
This Human DSG3 recombinant protein was produced in baculovirus, where the gene sequence encoding Human DSG3 (50-615aa) was expressed with the C-terminal 6xHis tag. The purity of this DSG3 protein was greater than 95% by SDS-PAGE. The activity was validated.
DSG3 (Desmoglein 3) is an autoantibody obtained from the serum of patients suffering from an autoimmune vesicle formation disease of the skin and mucous membranes—pemphigus vulgaris (PV). Immunoprecipitation, for the first time identified a glycoprotein with a molecular weight of 130 kDa, named PV antigen (PVA). DSG3 is closely related to dermatology and is the target of various autoimmune and some hereditary bullous diseases including pemphigus. More and more studies have shown that DSG3 may play an important role in the process of cell proliferation, apoptosis and migration. Therefore, DSG3 may be clinically relevant to the occurrence and development of squamous cell carcinoma. At present, the detection of serum anti-desmoglein DSG3 antibody has been used in the diagnosis of pemphigus, and plays a key role in the development of therapeutic candidate drugs and diagnostic kits for diseases such as pemphigus.