AADAT Antibody

Datasheet

Code	CSB-PA843276LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA843276LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA843276LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AADAT Polyclonal antibody

Uniprot No.

Q8N5Z0

Target Names

AADAT

Alternative Names

2 aminoadipate aminotransferase antibody; 2 aminoadipate transaminase antibody; 2-aminoadipate aminotransferase antibody; 2-aminoadipate transaminase antibody; Aadat antibody; AADAT_HUMAN antibody; Aadt antibody; AI875679 antibody; Alpha aminoadipate aminotransferase antibody; Alpha-aminoadipate aminotransferase antibody; Aminoadipate aminotransferase antibody; EC 2.6.1.39 antibody; EC 2.6.1.7 antibody; KAT/AadAT antibody; KAT2 antibody; KATII antibody; Kynurenine oxoglutarate transaminase 2 antibody; Kynurenine aminotransferase II antibody; Kynurenine oxoglutarate aminotransferase II antibody; Kynurenine oxoglutarate transaminase II antibody; Kynurenine--oxoglutarate aminotransferase II antibody; Kynurenine--oxoglutarate transaminase II antibody; Kynurenine/alpha-aminoadipate aminotransferase mitochondrial [Precursor] antibody; Kynurenine/alpha-aminoadipate aminotransferase; mitochondrial antibody; L kynurenine/alpha aminoadipate aminotransferase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial protein (30-425AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The AADAT Antibody (Product code: CSB-PA843276LA01HU) is Non-conjugated. For AADAT Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA843276LB01HU	AADAT Antibody, HRP conjugated	ELISA
FITC	CSB-PA843276LC01HU	AADAT Antibody, FITC conjugated
Biotin	CSB-PA843276LD01HU	AADAT Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Gene References into Functions

Immunohistochemical analysis revealed the presence of KAT I, II, and III in all examined corneal sections. PMID: 28706436
he optimised method of protein production provides a fast and reliable technique to generate large quantities of active human KAT2 suitable for future small-molecule lead compound screening and structural design work. PMID: 26773745
Participants with major depression had lower levels of kynurenine compared to controls, with intermediate concentrations in somatoform patients. PMID: 24140252
Somatization is characterized by disorders in kynurenine aminotransferase activity and an increased neurotoxic potential PMID: 21712776
association of SNP AADAT+401C/T with the host immune response to bacterial meningitis, suggesting that this SNP may affect the host ability in recruitment of leukocytes to the infection site PMID: 21473761
analysis of the crystal structure of kynurenine aminotransferase II PMID: 18056995
analysis of the crystal structure of human kynurenine aminotransferase II PMID: 18056996
A human cDNA encodes a 425-residue protein with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site, ~70% identical to the mouse and rat AADAT orthologs. Bacterial expression studies confirm that the gene encodes AADAT activity. PMID: 12126930

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Subcellular Location

Mitochondrion.

Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family

Tissue Specificity

Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.

Database Links

HGNC: 17929

OMIM: 611754

KEGG: hsa:51166

STRING: 9606.ENSP00000226840

UniGene: Hs.529735

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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