ABCA2 Antibody

Code CSB-PA887172LA01HU
Size US$299 How to order?
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA887172LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA887172LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ABCA2 Polyclonal antibody
Uniprot No. Q9BZC7
Target Names ABCA2
Alternative Names ABC2 antibody; Abca2 antibody; ABCA2_HUMAN antibody; ATP binding cassette 2 antibody; ATP binding cassette sub family A member 2 antibody; ATP binding cassette transporter 2 antibody; ATP binding cassette; sub family A (ABC1); member 2 antibody; ATP binding cassette; sub family A; member 2 antibody; ATP binding cassette; sub family B (MDR/TAP); member 2 antibody; ATP-binding cassette 2 antibody; ATP-binding cassette sub-family A member 2 antibody; ATP-binding cassette transporter 2 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human ATP-binding cassette sub-family A member 2 protein (1223-1429AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The ABCA2 Antibody (Product code: CSB-PA887172LA01HU) is Non-conjugated. For ABCA2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA887172LB01HU ABCA2 Antibody, HRP conjugated ELISA
FITC CSB-PA887172LC01HU ABCA2 Antibody, FITC conjugated
Biotin CSB-PA887172LD01HU ABCA2 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Gene References into Functions
  1. The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
  2. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
  3. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
  4. SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
  5. A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
  6. we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
  7. roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
  8. Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
  9. It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
  10. Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
  11. Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
  12. the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
  13. Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
  14. No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

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Subcellular Location Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Protein Families ABC transporter superfamily, ABCA family
Tissue Specificity [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.
Database Links

HGNC: 32

OMIM: 600047

KEGG: hsa:20

STRING: 9606.ENSP00000344155

UniGene: Hs.421202

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