ABCA2 Antibody

Datasheet

Code	CSB-PA949432
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA949432(ABCA2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q9BZC7

Target Names

ABCA2

Alternative Names

ABC2 antibody; Abca2 antibody; ABCA2_HUMAN antibody; ATP binding cassette 2 antibody; ATP binding cassette sub family A member 2 antibody; ATP binding cassette transporter 2 antibody; ATP binding cassette; sub family A (ABC1); member 2 antibody; ATP binding cassette; sub family A; member 2 antibody; ATP binding cassette; sub family B (MDR/TAP); member 2 antibody; ATP-binding cassette 2 antibody; ATP-binding cassette sub-family A member 2 antibody; ATP-binding cassette transporter 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human ABCA2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.

Gene References into Functions

The analyses results suggested ABCA2 mRNA expression was upregulated significantly in AD compared with controls in all datasets. PMID: 29224028
Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment. PMID: 24145140
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization. PMID: 22086926
SLC2A1/GLUT1, SLC1A3/EAAT1, and SLC1A2/EAAT2 were the main SLC proteins whereas ABCG2/BCRP, ABCB1/MDR1, ABCA2 and ABCA8 were the main ABC quantified in isolated brain microvessels PMID: 21707071
A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein processing, and Alzheimer's disease. PMID: 20704561
we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells PMID: 21041019
roles for this largest known ABC protein in neural transmembrane lipid export PMID: 12363033
Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 and Sp-family transcription factors. PMID: 12560508
It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues. PMID: 15093135
Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease. PMID: 15155565
Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples. PMID: 15649702
the expression patterns of ABCA2 in combination with other markers showed phenotypic heterogeneity in schwannomas PMID: 15850583
Data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic Alzheimer's disease and support a role of ABC lipid transporters in the pathogenesis of this disease. PMID: 16752360
No association of ABCA2 Single Nucleotide Polymorphism on chromosome 9 with Alzheimer's disease. PMID: 18336955

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Subcellular Location

Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Protein Families

ABC transporter superfamily, ABCA family

Tissue Specificity

[Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes.

Database Links

HGNC: 32

OMIM: 600047

KEGG: hsa:20

STRING: 9606.ENSP00000344155

UniGene: Hs.421202

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Related pathways

Cell markers

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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