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| Code | CSB-PA001053LC01HU |
| Size | US$299 How to order? |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Homo sapiens (Human) ABCB7 Polyclonal antibody |
| Uniprot No. | O75027 |
| Target Names | ABCB7 |
| Alternative Names | ABC transporter 7 protein antibody; ABC7 antibody; Abcb7 antibody; ABCB7_HUMAN antibody; ASAT antibody; Atm1p antibody; ATP binding cassette 7 antibody; ATP binding cassette sub family B (MDR/TAP) member 7 antibody; ATP binding cassette sub family B member 7 antibody; ATP binding cassette sub family B member 7 mitochondrial antibody; ATP binding cassette transporter 7 antibody; ATP-binding cassette sub-family B member 7 antibody; ATP-binding cassette transporter 7 antibody; EST140535 antibody; MDR7 antibody; mitochondrial antibody; Multidrug resistance protein 7 antibody; P-glycoprotein 7 antibody; PGP7 antibody |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Immunogen | Recombinant Human ATP-binding cassette sub-family B member 7, mitochondrial protein (23-140AA) |
| Immunogen Species | Homo sapiens (Human) |
| Conjugate | FITC |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis.
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| Gene References into Functions |
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| Involvement in disease | Anemia, sideroblastic, spinocerebellar ataxia (ASAT) |
| Subcellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. |
| Protein Families | ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3.A.1.210) subfamily |
| Database Links |
HGNC: 48 OMIM: 300135 KEGG: hsa:22 STRING: 9606.ENSP00000253577 UniGene: Hs.370480 |
