ABCG4 Antibody

1. Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes PMID: 27816548
2. ABCG1 and ABCG4 alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta secretion PMID: 27196068
3. Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4, whereas the ABCG2 multidrug transporter is unable to form a heterodimer with ABCG4. PMID: 27228027
4. Study suggests that high ABCG4 expression is associated with poor prognosis in patients with non-small-cell lung cancer with advanced stages. PMID: 26270652
5. HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity PMID: 26296893
6. These results suggest that ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane PMID: 25302608
7. This study demonstreated that Abcg4 acts in concert with Abcg2 to efflux Abeta from the brain across the blood-brain barrier. PMID: 22391220
8. Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4: maps to human chromosome 11, is expressed abundantly in brain, and has alternatively-spliced isoforms PMID: 11856881
9. ABCG4 is expressed specifically in the brain and the eye. PMID: 12183068
10. ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles PMID: 16902247
11. ABCG4 is highly expressed in microglia on alzheimer disease brain. PMID: 18508037
12. Human ABC transporters ABCG2 (BCRP) and ABCG4 PMID: 18668433
13. ABCG4 may be involved in macrophage lipid homeostasis. PMID: 11606068

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HGNC: 13884

OMIM: 607784

KEGG: hsa:64137

STRING: 9606.ENSP00000304111

UniGene: Hs.126378