ABI2 Antibody

Datasheet
Code CSB-PA001102LA01HU
See More Details Free Antibody trial simple
Size US$299Purchase it in Cusabio online store
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Uniprot No. Q9NYB9
Image
  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA001102LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001102LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA001102LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Abl interactor 2 protein (164-452AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Relevance May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1), ABI2, ARGBPIA
Immunogen Species Human
Research Area Cancer
Target Names ABI2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Subcellular Location Cytoplasm, SUBCELLULAR LOCATION: Isoform 1: Cell projection, lamellipodium, Cell projection, filopodium, Cytoplasm, cytoskeleton
Protein Families ABI family
Database Links

HGNC: 24011

OMIM: 606442

KEGG: hsa:10152

UniGene: Hs.471156

Pathway Regulation of actin cytoskeleton

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