ABI2 Antibody

Code CSB-PA001102LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA001102LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001102LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA001102LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ABI2 Polyclonal antibody
Uniprot No.
Target Names
ABI2
Alternative Names
Abelson interactor 2 antibody; ABI 2 antibody; Abi-2 antibody; ABI2 antibody; ABI2_HUMAN antibody; ABI2B antibody; Abl binding protein 3 antibody; Abl interacting protein 1 (SH3 containing protein) antibody; Abl interactor 2 antibody; Abl interactor protein 2b antibody; Abl-binding protein 3 antibody; AblBP3 antibody; AIP 1 antibody; Arg binding protein 1 antibody; Arg protein tyrosine kinase binding protein antibody; Arg-binding protein 1 antibody; ArgBP1 antibody; ARGBPIA antibody; ArgBPIB antibody; OTTHUMP00000163783 antibody; OTTHUMP00000163784 antibody; OTTHUMP00000206182 antibody; OTTHUMP00000206183 antibody; OTTHUMP00000206184 antibody; OTTHUMP00000206185 antibody; SSH3BP2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Abl interactor 2 protein (164-452AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The ABI2 Antibody (Product code: CSB-PA001102LA01HU) is Non-conjugated. For ABI2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA001102LB01HU ABI2 Antibody, HRP conjugated ELISA
FITC CSB-PA001102LC01HU ABI2 Antibody, FITC conjugated
Biotin CSB-PA001102LD01HU ABI2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
Gene References into Functions
  1. TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade PMID: 27932314
  2. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia. PMID: 22304832
  3. Abi-2 may have a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression PMID: 16488906
  4. disruption of the interaction between Bcr-Abl and Abi1 by mutations either in Bcr-Abl or Abi1 not only abolished tyrosine phosphorylation of Abi1 and membrane translocation of Abi1/WAVE2 PMID: 17389688
  5. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2 PMID: 18632609

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Subcellular Location
Cytoplasm. Nucleus.; [Isoform 1]: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Cell junction, adherens junction.
Protein Families
ABI family
Tissue Specificity
Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
Database Links

HGNC: 24011

OMIM: 606442

KEGG: hsa:10152

UniGene: Hs.471156

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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