ACMSD Antibody

Datasheet

Code	CSB-PA851554LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat liver tissue, Rat heart tissue All lanes: ACMSD antibody at 4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 39, 32 kDa Observed band size: 39 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA851554LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA851554LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA851554LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ACMSD Polyclonal antibody

Uniprot No.

Q8TDX5

Target Names

ACMSD

Alternative Names

2 amino 3 carboxymuconate 6 semialdehyde decarboxylase antibody; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase antibody; acmsd antibody; ACMSD_HUMAN antibody; Aminocarboxymuconate semialdehyde decarboxylase antibody; Picolinate carboxylase antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase protein (33-129AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ACMSD Antibody (Product code: CSB-PA851554LA01HU) is Non-conjugated. For ACMSD Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA851554LB01HU	ACMSD Antibody, HRP conjugated	ELISA
FITC	CSB-PA851554LC01HU	ACMSD Antibody, FITC conjugated
Biotin	CSB-PA851554LD01HU	ACMSD Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Gene References into Functions

The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters. PMID: 27483383
The crystal structures of the human enzyme in its native catalytically active state, a substrate analogue-bound form and a selected active site mutant form with one of the putative substrate binding residues altered, are reported. PMID: 25392945
ACMSD is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism. ACMSD mutation contributes to the development of Familial cortical myoclonic tremor and epilepsy. PMID: 23955123
Data report a crystal structure of human ACMSD in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP),suggesting a regulatory link between NAD synthesis and glycolysis. PMID: 19843166
identification and expression of cDNA PMID: 12140278

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Protein Families

Metallo-dependent hydrolases superfamily, ACMSD family

Database Links

HGNC: 19288

OMIM: 608889

KEGG: hsa:130013

STRING: 9606.ENSP00000348459

UniGene: Hs.655728

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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