ACSS2 Antibody

Code CSB-PA873629ESR2HU
Size US$166
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  • Western blot
    All lanes: ACSS2antibody at 2.14μg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse kidney tissue
    Lane 3: U87 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 79, 81 kDa
    Observed band size: 79 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA873629ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ACSS2 Polyclonal antibody
Uniprot No.
Target Names
ACSS2
Alternative Names
ACAS2 antibody; AceCS antibody; Acetate CoA ligase antibody; Acetate thiokinase antibody; Acetate--CoA ligase antibody; Acetyl CoA synthetase antibody; Acetyl Coenzyme A synthetase 2 (ADP forming) antibody; Acetyl coenzyme A synthetase cytoplasmic antibody; Acetyl-CoA synthetase antibody; Acetyl-coenzyme A synthetase antibody; ACS antibody; ACSA antibody; ACSA_HUMAN antibody; ACSS2 antibody; Acyl activating enzyme antibody; Acyl CoA synthetase short chain family member 2 antibody; Acyl-activating enzyme antibody; Acyl-CoA synthetase short-chain family member 2 antibody; Cytoplasmic acetyl coenzyme A synthetase antibody; cytoplasmic antibody; MYH7B antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Acetyl-coenzyme A synthetase, cytoplasmic protein (462-701AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity.
Gene References into Functions
  1. High ACSS2 expression is associated with renal cell carcinoma. PMID: 29503142
  2. A novel biologic role for ACSS2 in recycling of nuclear acetate for histone acetylation to promote lysosomal and autophagy-related gene expression and counteract nutritional stress, highlighting the importance of ACSS2 in maintaining autophagy and lysosome-mediated cellular energy homeostasis during tumor development. PMID: 28820290
  3. ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection. PMID: 28167750
  4. ACSS2 is an important factor for promoting RCC development and is essential for cell migration and invasion, which it promotes by increasing the expression of LAMP1. PMID: 29444517
  5. these findings suggest that downregulation of acetyl-CoA synthetase-2 expression is a metabolic hallmark of tumor progression and aggressive behavior in colorectal carcinoma. PMID: 27713423
  6. Exogenous acetate augments Acss2/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models PMID: 29281714
  7. The nuclear-cytosolic acetyl-CoA synthetase 2 recaptures acetate released from histone deacetylation for recycling by histone acetyltransferases. PMID: 28099844
  8. In a Honduran population, the odds of having nonsyndromic cleft lip/palate (NSCLP) among carriers of the ACSS2 variant was 4.0 with a carrier frequency of 7.1% in unrelated affected and 1.9% in unrelated unaffected individuals. In a Colombian population, the odds of having NSCLP among carriers of the ACSS2 variant was 2.6 with a carrier frequency of 10.0% in unrelated affected and 4.1% in unrelated unaffected individuals. PMID: 28543373
  9. In the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. PMID: 28552616
  10. ACSS2 is essential for glucose-independent acetate-mediated cell survival and tumor growth. PMID: 27539851
  11. Loss of ACSS2 expression is associated with with gastric cancer. PMID: 26381042
  12. Study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. PMID: 25584894
  13. Observations suggest that ACSS2 is expressed to a significant extent in particular tumor types, including triple-negative breast cancers. PMID: 25525877
  14. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine. In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2. PMID: 25525878
  15. During hypoxia, ACSS2 modulates interactions of the acetylase/coactivator CBP with the stress-responsive transcription factor, HIF-2. These interactions include acetylation of HIF-2 by CBP as well as stable HIF-2/CBP complex formation, both of which are required for maximal HIF-2 signaling. Thus, ACSS2 links changes in metabolism that occur during stress with activation of a selective nuclear signaling pathway. PMID: 25108527
  16. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals. PMID: 20353815
  17. Because the activity of a bacterial ortholog of AceCS2, called ACS, is controlled via deacetylation by a bacterial sirtuin protein, our observation highlights the conservation of a metabolic regulatory pathway from bacteria to humans PMID: 16788062
  18. The patterns of (18)F-FDG and (11)C-acetate uptake seemed to complement each other in both human HCC and HCC cell lines. PMID: 19617323

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
ATP-dependent AMP-binding enzyme family
Database Links

HGNC: 15814

OMIM: 605832

KEGG: hsa:55902

STRING: 9606.ENSP00000253382

UniGene: Hs.517034

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